Small Upconverting Fluorescent Nanoparticles for Biomedical Applications

Chatterjee, Dev; Gnanasammandhan, Muthu Kumara; Zhang, Yong

doi:10.1002/smll.201000418

Cited by 514 publications

(348 citation statements)

References 107 publications

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“…See DOI: 10.1039/c3dt50676b a Instituto de Ciencia de Materiales de Sevilla, CSIC-US, Americo Vespucio 49, 41092, Isla de la Cartuja, Sevilla, Spain. E-mail: nurianu@icmse.csic.es b molecules of biological interest is an important issue since they provide anchors for adding functional ligands such as antibodies and drugs 16 and affect the colloidal stability of nanoparticles suspensions as recently demonstrated for YVO 4 : Eu nanoparticles, 17 which are isostructural to those herein studied. However, among the above-mentioned reports dealing with Ln:GdVO 4 nanoparticles, only that by Kang et al was conducted using poly(acrylic) acid functionalized GdVO 4 spheres, which were above the nanometric size range (180 nm) and showed a rather irregular shape and a certain degree of aggregation.…”

Section: Nanocrystals)mentioning

confidence: 79%

Surface modified Eu:GdVO4 nanocrystals for optical and MRI imaging

et al. 2013

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A facile solvothermal route has been developed for the preparation of europium doped gadolinium orthovanadate nanoparticles (∼70 nm) with tetragonal structure, based on a homogenous precipitation reaction at 120°C from rare earth precursors (yttrium nitrate and europium nitrate) and sodium orthovanadate solutions using an ethylene glycol-water mixture as the solvent. The effects of the doping level on the luminescence properties were evaluated in order to find the optimum nanophosphors. These nanocrystals were successfully functionalized with amino (two step process) and carboxylate (one-pot process) groups provided by amino-dextran polymers (AMD) and polyacrylic acid (PAA), respectively. It was found that while the luminescent properties of both kinds of functionalized systems were similar, the colloidal stability of the PAA-modified sample was higher, because of which, it was selected to study their cytotoxicity and magnetic properties (relaxivity and phantom analyses) to assess their potentiality as multifunctional probes for both "in vitro" optical biolabels and negative contrast agents for magnetic resonance imaging.

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Section: Nanocrystals)mentioning

confidence: 79%

Surface modified Eu:GdVO4 nanocrystals for optical and MRI imaging

et al. 2013

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“…Thus, doping Ln 3+ cations into a sodium yttrium fluoride matrix NaYF 4 , especially one in the β-phase, leads to strong emissions from the f-f states of these ions owing to the longer lifetimes under such circumstances. These properties are especially well suited for the NIR to UV/visible upconversion nanoparticles (UCNPs) [69][70][71][72] that will be discussed in this section.…”

Section: Uncaging Using Upconversion Nanoparticles (A) Introduction Tmentioning

confidence: 99%

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Garcia

Zhang

Ford

2013

Phil. Trans. R. Soc. A.

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Multi-photon excitation allows one to use tissue transmitting near-infrared (NIR) light to access excited states with energies corresponding to single-photon excitation in the visible or ultraviolet wavelength ranges. Here, we present an overview of the application of both simultaneous and sequential multi-photon excitation in studies directed towards the photochemical delivery (‘uncaging’) of bioactive small molecules such as nitric oxide (NO) to physiological targets. Particular focus will be directed towards the use of dyes with high two-photon absorption cross sections and lanthanide ion-doped upconverting nanoparticles as sensitizers to facilitate the uncaging of NO using NIR excitation.

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“…37,38 Manipulation of IR radiation using UCNPs has been found to be of much interest because the UV-VIS output can be used to promote several chemical processes or to develop a number of applications in the fields of lighting and displays, energy, photocatalysis, sensing, bioanalytics and theranostics. [39][40][41][42][43][44][45] Up to our knowledge, only two reports concerning the inclusion of UCNPs in self-assembled organogels are available in the literature.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Light-Harvesting Soft Hybrid Materials: Assisted Energy Transfer upon Thermally Reversible Gelation

et al. 2017

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Multimodal light-harvesting soft systems able to absorb UV-to-NIR radiations and convert into visible emissions have drawn much attention in the last years in order to explore new areas of application in energy, photonics, photocatalysis, sensors and so forth. Here, we present a new hybrid system combining a supramolecular photonic gel of naphthalimide-derived molecules self-assembled into fibers and upconverting NaYF 4 :Yb/Tm nanoparticles (UCNPs). The hybrid system presented here manipulates light reversibly as a result of an optical communication between the UCNPs and the photoactive gel network. Upon UV irradiation, the system shows the characteristic emission at 410 nm from the photoactive organomolecule. This emission is also activated upon 980 nm excitation thanks to an efficient energy transfer from the UCNPs to the fibrillary network. Interestingly, the intensity of this emission is thermally regulated during the reversible assembly or disassembly of the organogelator molecules, in such a way that gelator emission is only observed in the aggregated state. Additionally, the adsorption of the UCNPs with the supramolecular gel fibers enhance their emissive properties, a behavior ascribed to the isolation from solvent quenchers and surface defects, as well as an increased IR light scattering promoted by the fibrillary network. The reported system constitutes a unique case of a thermally regulated, reversible, dual UV and IR light harvesting hybrid soft material.3

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Small Upconverting Fluorescent Nanoparticles for Biomedical Applications

Cited by 514 publications

References 107 publications

Surface modified Eu:GdVO4 nanocrystals for optical and MRI imaging

Surface modified Eu:GdVO4 nanocrystals for optical and MRI imaging

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Multimodal Light-Harvesting Soft Hybrid Materials: Assisted Energy Transfer upon Thermally Reversible Gelation

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