“Small stem cells” in adult tissues: Very small embryonic‐like stem cells stand up!

Zuba‐Surma, Ewa; Kucia, Magda; Ratajczak, Janina; Ratajczak, Mariusz Z.

doi:10.1002/cyto.a.20665

Cited by 100 publications

(58 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another cell type showing promising preclinical results are very small embryonic-like stem cells, which are discussed in more detail by Zuba-Surma et al in this issue of the journal (95). The results of the preclinical trials initiated a variety of clinical studies for restoring myocardial function in patients suffering from acute myocardial infarction.…”

Section: Review Articlementioning

confidence: 99%

Endothelial progenitor cells: Implications for cardiovascular disease

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: Review Articlementioning

confidence: 99%

Endothelial progenitor cells: Implications for cardiovascular disease

et al. 2008

View full text Add to dashboard Cite

show abstract

“…During mitosis, stem cells renew themselves, e.g., at least one of the daughter cells preserves its ''stemness''. However, stem cells can exhibit an impressive proliferative capacity upon tissue injury or in culture (41)(42)(43)(44)(45)(46). The slow cycling of limbal stem cells allowed their detection as label retaining cells (13).…”

Section: Characteristics Of Limbal Epithelial Stem Cellsmentioning

confidence: 99%

Stem cells of the adult cornea: From cytometric markers to therapeutic applications

et al. 2008

View full text Add to dashboard Cite

The cornea is a major protective shield of the interior of the eye and represents two thirds of its refractive power. It is made up of three tissue layers that have different developmental origins: the outer, epithelial layer develops from the ectoderm overlying the lens vesicle, whereas the stroma and the endothelium have mesenchymal origin. In the adult organism, the outermost corneal epithelium is the most exposed to environmental damage, and its constant renewal is assured by the epithelial stem cells that reside in the limbus, the circular border of the cornea. Cell turnover in the stromal layer is very slow and the endothelial cells probably do not reproduce in the adult organism. However, recent experimental evidence indicates that stem cells may be found in these layers. Damage to any of the corneal layers leads to loss of transparency and low vision. Corneal limbal stem cell deficiency results in severe ocular surface disease and its treatment by transplantating ex vivo expanded limbal epithelial cells is becoming widely accepted today. Stromal and endothelial stem cells are potential tools of tissue engineering and regenerative therapies of corneal ulcers and endothelial cell loss. In the past few years, intensive research has focused on corneal stem cells aiming to improve the outcomes of the current corneal stem cell transplantation techniques. This review summarizes the current state of knowledge on corneal epithelial, stromal and endothelial stem cells. Special emphasis is placed on the molecular markers that may help to identify these cells, and the recently revealed mechanisms that could maintain their ''stemness'' or drive their differentiation. The techniques for isolating and culturing/ expanding these cells are also described. '

show abstract

“…However, 2 years ago a unique adult pluripotent stem cell population, the very small embryonic-like stem cells (VSELs) were discovered in murine bone marrow (6) and have consequently become the subject of investigation in various other murine and human tissues as well. They have now been detected in several adult organs of the mouse and the data being covered in a recent Rapid Publication of the journal (7).They are further characterized in this focus issue in the context of other ''small stem cell'' populations described in the literature (8).…”

mentioning

confidence: 97%