Small size silver nanoparticles loaded with glycoside rich portion of Boerhavia Diffusa Linn. promotes wound healing: in-silico and in-vivo studies

Patil, Shweta; Ganeshpurkar, Ankit; Shrotriya, Shilpa; Sawant, Pooja; Mulgund, Sugandha

doi:10.1016/j.colsurfb.2023.113483

Cited by 4 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, nanohydrogels can be customized to control the gradual release of active substances, providing advantages in long-term therapy. Furthermore, nanohydrogels can overcome several obstacles often faced by liposomes, phytosomes, and micelles, such as better stability in various environmental conditions and the ability to transport various active substances [48][49][50].…”

Section: Nanohydrogel-based Drug Delivery System For Natural Product ...mentioning

confidence: 99%

“…In addition, the parenteral route nanohydrogel has good conductivity as it can move in the fine capillaries because of its small size. Thus, the nanohydrogel formulation is a better delivery system for natural product compounds or phytochemical compounds than hydrogel systems [49][50][51].…”

Section: Nanohydrogel-based Drug Delivery System For Natural Product ...mentioning

confidence: 99%

“…These findings confirm that protein encapsulation in lipid vesicles in the matrix space in a gel network system enhances the local action of drugs on the skin, reduces their systemic toxicity, and increases drug retention in skin epithelial cells. Thus, 1% (w/w) protein nanohydrogel preparations have therapeutic potential for managing precancerous skin lesions [50][51][52]. The nanohydrogel dosage form is beneficial not only for oral but also for topical use.…”

Section: Nanohydrogel-based Drug Delivery System For Natural Product ...mentioning

confidence: 99%

See 2 more Smart Citations

Improved Solubility and Activity of Natural Product in Nanohydrogel

Lestari,

Muhaimin,

Chaerunisaa

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

With the development of technology, natural material components are widely used in various fields of science. Natural product components in phytochemical compounds are secondary metabolites produced by plants; they have been shown to have many pharmacological activities. Phytochemical compounds obtained from plants have an important role in herbal medicine. Herbal medicine is safer and cheaper than synthetic medicine. However, herbal medicines have weaknesses, such as low solubility, less stability, low bioavailability, and experiencing physical and chemical degradation, reducing their pharmacological activity. Recent herbal nano-delivery developments are mostly plant-based. A nanotechnology-based system was developed to deliver herbal therapies with better bioavailability, namely the nanohydrogel system. Nanohydrogel is a delivery system that can overcome the disadvantages of using herbal compounds because it can increase solubility, increase pharmacological activity and bioavailability, reduce toxicity, slow delivery, increase stability, improve biodistribution, and prevent physical or chemical degradation. This review article aimed to provide an overview of recent advances in developing nanohydrogel formulations derived from natural ingredients to increase solubility and pharmacological activity, as well as a summary of the challenges faced by delivery systems based on nanohydrogel derived from natural materials. A total of 25 phytochemicals derived from natural products that have been developed into nanohydrogel were proven to increase the activity and solubility of these chemical compounds.

show abstract

Section: Nanohydrogel-based Drug Delivery System For Natural Product ...mentioning

confidence: 99%

Section: Nanohydrogel-based Drug Delivery System For Natural Product ...mentioning

confidence: 99%