Small Size Nanosilver Multi Organ Toxicity: A Higher Dose Negative Response in In-Vivo and In-Vitro Experimental Application

Pulmonary and hepatic effects after low dose exposure to nanosilver: Early and long-lasting histological and ultrastructural alterations in rat

“…AgNPs have been shown to be extremely toxic in small dimension (less than 20 nm), with faster rates of Ag dissolution, but teratogenic in bigger size and larger doses. Additionally, AgNPs produce various toxogenic responses [[53], [54], [55]], also triggering organ toxicity and inflammatory responses after repeated oral administration in vivo [56]. However, despite different exposure routes and animal species have been tested, to deeply comprehend AgNPs kinetics, tissue distribution and overall toxicity [17], the toxicological data coming from in vivo studies are still contentious and need to be cautiously interpreted since high unrealistic doses have been often employed.…”

The Effects of Combined toxicity of Silver and Silicon Nanoparticles on Hematological and Biochemical Parameters in Male Albino Mice

“…"Dziendzikowska" [35] suggested that the liver is the first line of defense against NPs, for that the deposition of the non-biodegradable nanoparticles are likely to occur. Although the amount of these particles is translocated to other organs like the kidney and spleen [36,37]. An accumulation of AgNPs after intraperitoneal exposure in body organs mostly the liver and kidneys, were observed by Razooki [38].…”