Small‐Scale Robots in Fluidic Media

Kósa, Gábor; Hunziker, Patrick

doi:10.1002/aisy.201900035

Cited by 9 publications

(6 citation statements)

References 112 publications

(181 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The robotic pill is rotated along its longitudinal axis, producing displacement by each magnetic field turn. [46][47][48][49][50][51] The robotic pill can be guided through predetermined paths, as illustrated in Figure 4b, which shows the overlap of multiple images taken from Video S3, Supporting Information. This locomotion mechanism can be used to navigate the structure over complex and uneven routes.…”

Section: Resultsmentioning

confidence: 99%

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Soto

Purcell

Özen

et al. 2022

Advanced Intelligent Systems

View full text Add to dashboard Cite

Health relevant information is coded in circulating signatures or biomarkers, such as the secretome, extracellular vesicles, nucleic acids, bacteria, and other markers. [1][2][3] The collection and analysis of such signatures can serve as an early sign of disease initiation and its progression through repeated sampling. [4][5][6][7][8][9][10] Nevertheless, it remains a challenge to isolate or sample biomarkers from regions of the body with limited accessibility, such as the gastrointestinal (GI) tract, which is more than 9 meters in total length. [11,12] To gain access to these challenging locations, invasive medical procedures, such as surgery, biopsies, and colonoscopies, are required to extract information, limiting the repeatability of such measurements. [13][14][15] These techniques involve trained practitioners, expensive instruments, and specialized facilities, making them hard to expand to a large population. In contrast, minimally invasive approaches can also be used for sampling biomarkers. [16] For instance, liquid biopsy is a standard approach to obtain a snapshot of the signature pool from biofluids (blood, urine, or stool samples). [17,18] Although useful, liquid biopsy frequently provides indirect data that is averaged across the sample and not specific to a particular region of the body.Smart pills have been deployed as a method to investigate cavities inside the body. [19][20][21][22][23][24] For instance, the PillCam, an ingestible capsule with an embed camera, is commonly used to search for polyps in the GI. [25][26][27][28][29][30][31][32][33] More recently, smart pills have been applied to capture and sense biomarkers through lab-on-a-chip systems, [26][27][28] osmotic gradients, [29] and passive absorption in refs. [30][31][32] methods. The ability to isolate biomarkers within localized environments

show abstract

Section: Resultsmentioning

confidence: 99%

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Soto

Purcell

Özen

et al. 2022

Advanced Intelligent Systems

View full text Add to dashboard Cite

show abstract

“…The robotic pill is rotated along its longitudinal axis, producing displacement by each magnetic field turn. (Tu and Gao, 2020;Hu et al, 2018;Lee et al, 2022;Xu et al, 2022;Sayed et al, 2022;Kosa and Hunziker, 2019) The robotic pill can be guided through predetermined paths, as illustrated in Figure 5c, which shows the overlap of multiple images taken from Video S3.…”

Section: Results and Disscussionmentioning

confidence: 99%

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Soto

Purcell

Özen

et al. 2022

Preprint

View full text Add to dashboard Cite

Developing on-site biomarker enrichment platforms could help to improve the diagnosis of gastrointestinal (GI) tract diseases at early stages. Medical procedures, such as colonoscopies and imaging techniques, are used to diagnose disease, but are not easily accessible for repeat measurements. In the other hand, liquid biopsies, e.g., blood, urine, or fecal samples, have become important sampling strategies to identify health concerns. Herein, a robotic pill is designed for collecting relevant biomarkers from the GI over prolonged sampling periods. The robotic pill comprises a magnetic core for locomotion, a delayed gate mechanism that controls sampling location based on changes in its environment, and an enrichment module that traps biomarkers in an absorbent matrix while enabling biofluid to pass through the chamber. The robotic pill was assessed to sample microparticles, proteins, and bacteria from solution. Moreover, the robotic pill was capable of directed locomotion in complex environments and docking in a targeted region against fluid flow. Utilization of an untethered robotic sampling system could provide a tool to investigate aspects of disease initiation and progression for early diagnosis and therapy monitoring.

show abstract

“…Moreover, being observable enables flexible actuator manipulations including rotation, lifting, and flipping. The fine motion control of magnetic actuators makes it possible to precisely locate and even tune the force exerted on the inner wall of the intestine [ 40 ], uterus [ 103 ], and stomach [ 104 , 105 ]. Hwasaki et al reported a soft patch remover driven by a magnetic actuator, shown in Figure 3 d [ 106 ].…”

Section: Actuators For Various In Vivo Biomedical Applicationsmentioning

confidence: 99%

Actuators for Implantable Devices: A Broad View

Yan

2022

Micromachines

View full text Add to dashboard Cite

The choice of actuators dictates how an implantable biomedical device moves. Specifically, the concept of implantable robots consists of the three pillars: actuators, sensors, and powering. Robotic devices that require active motion are driven by a biocompatible actuator. Depending on the actuating mechanism, different types of actuators vary remarkably in strain/stress output, frequency, power consumption, and durability. Most reviews to date focus on specific type of actuating mechanism (electric, photonic, electrothermal, etc.) for biomedical applications. With a rapidly expanding library of novel actuators, however, the granular boundaries between subcategories turns the selection of actuators a laborious task, which can be particularly time-consuming to those unfamiliar with actuation. To offer a broad view, this study (1) showcases the recent advances in various types of actuating technologies that can be potentially implemented in vivo, (2) outlines technical advantages and the limitations of each type, and (3) provides use-specific suggestions on actuator choice for applications such as drug delivery, cardiovascular, and endoscopy implants.

show abstract

Small‐Scale Robots in Fluidic Media

Cited by 9 publications

References 112 publications

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Actuators for Implantable Devices: A Broad View

Contact Info

Product

Resources

About