Saffl ower (Carthamus tinctorius L.), which has deep roots, can be grown as an economical oil crop in semiarid, rain-fed areas of West Asia and North Africa, where barley (Hordeum vulgare L.) monoculture is a common practice. In this study, we sought to: (i) evaluate the eff ect of saffl ower on the yield of the following barley crop and (ii) compare such eff ect with other crops to determine the potential of rotating saffl ower with barley. Two series of experiments were conducted under rain-fed conditions in Lebanon's Bekaa Valley ). In Series 1, there were 12 2-yr rotation systems, whereas in Series 2, 3 rotation systems were studied. Results from the two and three rotation cycles were reported from the fi rst and second series of experiments, respectively. Rotation eff ects were signifi cant (P ≤ 0.05) for barley grain yield, straw yield, and harvest index, but rotation × year interaction was not signifi cant. In Series 1, barley aft er saffl ower gave the highest harvest index (0.40 kg kg -1 ) and mean grain yield (1400 kg ha -1 ), that is, 28 to 72% higher grain yield than aft er the other crops, except aft er cumin (Cuminum cyminum L.) and common vetch (Vicia sativa L.) for grazing. In Series 2, grain yield and harvest index of barley aft er saffl ower (4090 kg ha -1 , 0.36 kg kg -1 ) were higher than that aft er barley (3010 kg ha -1 , 0.32 kg kg -1 ). Th us, growing saffl ower before barley increased rather than decreased barley yields, and was comparable to or better than aft er some legumes. Barley/saffl ower therefore appears to be a viable rotation in semiarid, rain-fed Mediterranean areas.