“…8 In contrast to healthy adaptation, not only myomiRs are regulated in cancer cachexia, a recent publication showed an up-regulation of hsa-miR-3184-3p, hsa-miR-423-5p, hsa-let-7d-3p, hsa-miR-1296-5p, hsa-miR-345-5p, hsa-miR-532-5p, hsa-miR-423-3p, and hsa-miR-199a-3p, but no down-regulation of miRs in skeletal muscle biopsies of patients with pancreatic and colorectal cancer ( Table 1). 9 In a rat model of paralysed muscle by spinal cord injury, a down-regulation of miRs 23a, 23b, 27b, 145, and 206 was observed 56 days after injury, 10 while injection of 30 μg of mir-206 attenuated muscle loss in a rat denervation model. 11 In patients with chronic obstructive pulmonary disease (COPD), an up-regulation of miR-542-3p/5p in quadricep muscle has been described, which caused muscle wasting and reduced mitochondrial function when overexpressed in mice possibly due to a suppression of the mitochondrial ribosomal protein MRPS10, reduced 12S ribosomal RNA expression, and increased TGF-b signalling.…”