Small RNA-mediated prevention, diagnosis and therapies of cancer

Hasan, Abdullah Al; Azam, A.T.M. Zafrul

doi:10.1016/b978-0-12-813669-0.00009-9

Cited by 2 publications

(2 citation statements)

References 553 publications

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“…These particles were then coated with biodegradable cationic cross-linked polymers, namely poly-Arg-J8, poly-Arg, mannosylated poly-Arg and poly-Lys, to produce polyelectrolyte complexes PEC-1 to PEC-4 , respectively. Based on previous studies, many formulations including poly-Arg and poly-Lys were used safely in vivo without showing any level of toxicity [ 9 , 37 , 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Development of Multilayer Nanoparticles for the Delivery of Peptide-Based Subunit Vaccine against Group A Streptococcus

et al. 2022

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Peptide-based subunit vaccines include only minimal antigenic determinants, and, therefore, are less likely to induce allergic immune responses and adverse effects compared to traditional vaccines. However, peptides are weakly immunogenic and susceptible to enzymatic degradation when administered on their own. Hence, we designed polyelectrolyte complex (PEC)-based delivery systems to protect peptide antigens from degradation and improve immunogenicity. Lipopeptide (LCP-1) bearing J8 B-cell epitope derived from Group A Streptococcus (GAS) M-protein was selected as the model peptide antigen. In the pilot study, LCP-1 incorporated in alginate/cross-linked polyarginine-J8-based PEC induced high J8-specific IgG antibody titres. The PEC system was then further modified to improve its immune stimulating capability. Of the formulations tested, PEC-4, bearing LCP-1, alginate and cross-linked polylysine, induced the highest antibody titres in BALB/c mice following subcutaneous immunisation. The antibodies produced were more opsonic than those induced by mice immunised with other PECs, and as opsonic as those induced by antigen adjuvanted with powerful complete Freund’s adjuvant.

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Section: Resultsmentioning

confidence: 99%

Development of Multilayer Nanoparticles for the Delivery of Peptide-Based Subunit Vaccine against Group A Streptococcus

et al. 2022

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“…Although SBNs have been proposed to overcome limitations, such as cytotoxicity and low cellular uptake efficiencies, they often become trapped in endosomes. The strategy of combining dendrimers with SBNs can bypass some of these limitations, as these NPs may induce a proton sponge effect and thus escape from the endosomes [ 135 ]. Tianyu et al (2016) produced Se-shell–Pt-core coordination dendrimers that demonstrated anticancer activity without the conjugation of drugs in vivo in cancer tissue with no adverse effects on normal tissue [ 136 ].…”

Section: Dendrimers and Inorganic Nanoparticlesmentioning

confidence: 99%

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

2023

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The formulation of nanoscale systems with well-defined sizes and shapes is of great interest in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are polymers that have attracted interest due to their size, shape, branching length, amine density, and surface functionalities. These unique characteristics of dendrimers set them apart from other polymers, their ability to modify nanoparticles (NPs) for biomedical applications. Dendrimers are spherical with multiple layers over their central core, each representing a generation. Their amphiphilic nature and hollow structure allow for the incorporation of multiple drugs or genes, in addition to enabling easy surface modification with cellular receptor-targeting moieties to ensure site-specific delivery of therapeutics. Dendrimers are employed in chemotherapeutic applications for the delivery of anticancer drugs. There are many inorganic NPs currently being investigated for cancer therapy, each with their own unique biological, chemical, and physical properties. To favor biomedical applications, inorganic NPs require suitable polymers to ensure stability, biodegradability and target specificity. The success of dendrimers is dependent on their unique structure, good bioavailability and stability. In this review, we describe the properties of dendrimers and their use as modifiers of inorganic NPs for enhanced therapeutic delivery. Herein, we review the significant developments in this area from 2015 to 2022. Databases including Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), and PubMed were searched for articles using dendrimers, inorganic nanoparticles and cancer as keywords.

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Small RNA-mediated prevention, diagnosis and therapies of cancer

Cited by 2 publications

References 553 publications

Development of Multilayer Nanoparticles for the Delivery of Peptide-Based Subunit Vaccine against Group A Streptococcus

Development of Multilayer Nanoparticles for the Delivery of Peptide-Based Subunit Vaccine against Group A Streptococcus

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

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