Small protein blockers of human IL-6 receptor alpha inhibit proliferation and migration of cancer cells
Yaroslava Groza,
Lukáš Lacina,
Milan Kuchař
et al.
Abstract:Background
Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) complex is critical in tumor progression and, therefore, IL-6R represents an important therapeutic target.
Methods
An albumin-binding domain-derived highly complex combinatorial library was used to select IL-6R alpha (IL-6Rα)-target… Show more
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