Small Plastics, Big Inflammatory Problems

Prado, Yolanda; Aravena, Cristobal; Aravena, Diego; Eltit, Felipe; Gatica, Sebastián; Riedel, Claudia A.; Simón, Felipe

doi:10.1007/978-3-031-26163-3_6

Cited by 2 publications

(2 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was the result of multiple involvements of cellular derangement like liver lipid influx/efflux, mitochondrial dysfunction leading to hepatic inflammation and epigenetic reprogramming. Therefore, it can be conceded that exposure to EDCs like BPA might play a crucial role in NAFLD initiation and evolution 112 …”

Section: Bisphenol a And Liver Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Sangwan,

Bhattacharyya,

Banerjee

2024

Liver International

View full text Add to dashboard Cite

Plastics, while providing modern conveniences, have become an inescapable source of global concern due to their role in environmental pollution. Particularly, the focus on bisphenol A (BPA) reveals its biohazardous nature and association with liver issues, specifically steatosis. However, research indicates that BPA is just one facet of the problem, as other bisphenol analogues, microplastics, nanoplastics and additional plastic derivatives also pose potential risks. Notably, BPA is implicated in every stage of non‐alcoholic fatty liver disease (NAFLD) onset and progression, surpassing hepatitis B virus as a primary cause of chronic liver disease worldwide. As plastic contamination tops the environmental contaminants list, urgent action is needed to assess causative factors and mitigate their impact. This review delves into the molecular disruptions linking plastic pollutant exposure to liver diseases, emphasizing the broader connection between plastics and the rising prevalence of NAFLD.

show abstract

Section: Bisphenol a And Liver Diseasesmentioning

confidence: 99%

“…Several forms of plastic are toxic to liver. Below we try to summarize the studies highlighting plastic material–induced toxicities on liver 112 …”

Section: Macro Micro Nanoplastics Induced Liver Toxicitymentioning

confidence: 99%

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Sangwan,

Bhattacharyya,

Banerjee

2024

Liver International

View full text Add to dashboard Cite

show abstract

Pollutants, microbiota and immune system: frenemies within the gut

Rio,

Gasbarrini,

Gambassi

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite a widespread lack of awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing its regulation and triggering pro-inflammatory responses. The exposure to several pollutants also leads to alterations in gut microbiota with a decreasing abundance of beneficial microbes, such as short-chain fatty acid-producing bacteria, and an overgrowth of pro-inflammatory species. The subsequent intestinal barrier dysfunction, together with oxidative stress and increased inflammatory responses, plays a role in the pathogenesis of gastrointestinal inflammatory diseases. Moreover, pollutants encourage the inflammation-dysplasia-carcinoma sequence through various mechanisms, such as oxidative stress, dysregulation of cellular signalling pathways, cell cycle impairment and genomic instability. In this narrative review, we will describe the interplay between pollutants, gut microbiota, and the immune system, focusing on their relationship with inflammatory bowel diseases and colorectal cancer. Understanding the biological mechanisms underlying the health-to-disease transition may allow the design of public health policies aimed at reducing the burden of disease related to pollutants.

show abstract

Small Plastics, Big Inflammatory Problems

Cited by 2 publications

References 118 publications

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Pollutants, microbiota and immune system: frenemies within the gut

Contact Info

Product

Resources

About