Small peptide fingerprint (peptidomics) of Amyotrophic Lateral Sclerosis in CSF
Rea Lumi,
Susanne Petri,
Justyna Siwy
et al.
Abstract:BackgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by abnormal protein aggregates in motor neurons. Present and earlier proteomic studies to characterize peptides in cerebrospinal fluid (CSF) associated with motoneuron pathology did not target the low molecular weight proteins and peptides. We generated the hypothesis that specific changes in CSF peptides or low molecular weight proteins are significantly changed in ALS, and that these changes may support deciphering mol… Show more
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