Small organometallic compounds as antibacterial agents

Abstract

The emergence of bacterial resistance to commercial antibiotics is an issue of global importance. During the last two decades, the number of antibacterial agents that have been discovered and introduced into the market has steadily declined and failed to meet the challenges posed by rapidly increasing resistance of the pathogens against common antibacterial drugs. The development of new classes of compounds to control the virulence of the pathogens is therefore urgently required. This perspective describes the historical development in brief and recent advances on the preparation of small organometallic compounds as new classes of antibacterial agents with potential for clinical development. ABSTRACT.The emergence of bacterial resistance to commercial antibiotics is an issue of global importance.During the last two decades, the number of antibacterial agents that have been discovered and introduced into the market has steadily declined and failed to meet the challenges posed by rapidly increasing resistance of the pathogens against common antibacterial drugs. The development of new classes of compounds to control the virulence of the pathogens is therefore urgently required. This perspective describes the historical development in brief and recent advances on the preparation of small organometallic compounds as new classes of antibacterial agents with potential for clinical development. 3Introduction.

Ferrocenyl Derivatives of the Anthelmintic Praziquantel: Design, Synthesis, and Biological Evaluation

“…[13][14][15][16][17][18][19][20][21][22][23][24][25][26] This strategy was found very successful with ferroquine (FQ), a ferrocenyl analogue of the antimalarial drug chloroquine (CQ), as FQ is active on CQ-resistant Plasmodium falciparum strains. Furthermore, intensive chemical biology studies have recently allowed unveiling additional modes of action for FQ compared to the parent drug in FQ, which were attributed to the presence of the organometallic unit.…”

Oxidatively Locked [Co2L3]6+ Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole “Click” Ligands: Synthesis, Stability, and Antimicrobial Studies

“…With pathogens developing a resistance to beta-lactams and other commonly used antibiotics, the need for new antimicrobial medicines is growing. Metal-containing antibacterial drugs have become a global research focus over the past decade and are showing increasing promise [53][54][55]. As the previously Additional stability tests, in D 2 O, were also conducted with the [Co 2 L2 3 ](OTf) 6 cylinder against the common biological nucleophiles histidine and chloride ions.…”

Transition metal bioconjugates with an organometallic link between the metal and the biomolecular scaffold

“…Since the approval of cisplatin and related coordination complexes as anticancer drugs, research towards new organometallic compounds that avoid the serious side effects of these chemotherapy drugs has been greatly intensified [7,9]. Considering that most of these new antitumor-active complexes lack a biomolecular ligand, this area is not further treated here.…”