Small nuclear ribonucleoprotein antigens are absent from 10S translation inhibitory ribonucleoprotein but present in cytoplasmic messenger ribonucleoprotein and polysomes

Autoantibodies directed against a ribosomal small subunit protein of 20,000 molecular weight were found in sera from 5 of 44 patients with systemic lupus erythematosus (11%) and 5 of 48 MRLllpr mice (10%). This ribosomal protein was identified as S10 on the basis of two-dimensional gel electrophoresis and immunoblotting, as well as immunoblots of the purified S10 protein. The S10 protein antigen was readily extracted from ribosomes at low salt (300 mM KCI) and low magnesium (0.5 mM) concentrations, consistent with the highly exposed location proposed for this protein on the 40s subunit. Anti-SlO antibodies were observed significantly more frequently in lupus sera containing both anti-Sm and antiribosomal P protein antibodies and in MRLlZpr sera with anti-Sm activity, suggesting a linked pattern of autoantibody response. Together with anti-Sm and antiribosomal P protein antibodies, anti410 represents a third autoantibody highly specific for lupus in humans and MLRllpr mice.

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Antiribosomal S10 antibodies in humans and MRL/lpr mice with systemic lupus erythematosus

Bonfá

Parnassa

Rhoads

et al. 1989

Arthritis & Rheumatism

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Protein biosynthesis and autoimmunity

Sidorik

1992

Biopolym. Cell

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В огляді наведено літературні дані про особливості аутоантитілогенезу до деяких компонентів апарату трансляції. Розглянуто приклади виявлення аутоантитіл до аміноацил-тРНК синтетаз, рибосом та рибосомних білків за певних аутоімунних патологій. частково охарактеризовано їх властивості порівняно з. структурно-функціональними особливостями аутоантитіл до інших типів клітинних RNP-як цитоплазматичних, так і ядерних. Подано основні гіпотези походження аутоантитіл та їх функціонального значення в нормі і за імунопатологій.

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Small nuclear ribonucleoprotein antigens are absent from 10S translation inhibitory ribonucleoprotein but present in cytoplasmic messenger ribonucleoprotein and polysomes

Cited by 2 publications

References 57 publications

Antiribosomal S10 antibodies in humans and MRL/lpr mice with systemic lupus erythematosus

Antiribosomal S10 antibodies in humans and MRL/lpr mice with systemic lupus erythematosus

Protein biosynthesis and autoimmunity

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