Small molecules as cancer targeting ligands: Shifting the paradigm

Kaur, Navjeet; Popli, Pankaj; Tiwary, Neha; Swami, Rajan

doi:10.1016/j.jconrel.2023.01.032

Cited by 29 publications

(18 citation statements)

References 151 publications

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“…74,80 In addition to the peptide family, glucose metabolism can be targeted via glucose transporters. 75,77,82 Proteins such as transferrin and apolipoproteins have also been employed as targeting moieties. 74,83,84 Furthermore, a range of vitamins have been utilized as cancer targeting ligands.…”

Section: Phototherapymentioning

confidence: 99%

“…74,83,84 Furthermore, a range of vitamins have been utilized as cancer targeting ligands. 75 In recent years, the combination of fluorescence imaging and phototherapy, in the form PDT, PTT, or multimodal PDT + PTT, on a single PS has emerged as a striking approach. These theranostic PSs enable the selective treatment and imaging of cancer cells at the same time.…”

Section: Phototherapymentioning

confidence: 99%

“…One option in this direction is to utilize cell surface receptors (e.g., biotin, folate, human epidermal growth factor, etc.) that are differentially expressed in cancer cells. − To this end, PSs are modified with specific groups that can bind to the receptor of interest selectively. Tumor-homing peptides, which are capable of penetrating the cell membrane, recognizing tumor-related antigens or proteins, and binding to specific cell surfaces, are highly popular.…”

Section: Introductionmentioning

confidence: 99%

“…Tumor-homing peptides, which are capable of penetrating the cell membrane, recognizing tumor-related antigens or proteins, and binding to specific cell surfaces, are highly popular. The most well-known tumor-homing peptide, RGD, is composed of a tripeptide chain (Arg-Gly-Asp) and binds to integrins α V β 3 and α V β 5 . ,, NGR is also composed of a tripeptide chain (Asp-Gly-Arg) and exhibits specific selectivity toward aminopeptidase N. , Chlorotoxins, a small group of peptide toxins derived from scorpion venom, have been employed as targeting units in various studies, but they are particularly used for glioblastoma. , In addition to the peptide family, glucose metabolism can be targeted via glucose transporters. ,, Proteins such as transferrin and apolipoproteins have also been employed as targeting moieties. ,, Furthermore, a range of vitamins have been utilized as cancer targeting ligands …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hydrogen Sulfide Responsive Phototherapy Agents: Design Strategies and Biological Applications

Dirak

Turan

Kölemen

2023

ACS Bio Med Chem Au

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Hydrogen sulfide (H2S) is one of the critical gasotransmitters, which play important roles in regular physiological processes, especially in vital signaling pathways. However, fluctuations in endogenous H2S concentration can be linked to serious health problems, such as neurodegenerative diseases, cancer, diabetes, inflammation, cardiovascular diseases, and hypertension. Thus, it has attracted a great deal of attention in therapeutic applications, specifically in the field of phototherapy. Photodynamic therapy (PDT) and photothermal therapy (PTT) are two subclasses of phototherapy, which utilize either reactive oxygen species (ROS) or local temperature increase upon irradiation of a photosensitizer (PS) to realize the therapeutic action. Phototherapies offer unique advantages compared to conventional methods; thus, they are highly promising and popular. One of the design principles followed in new generation PSs is to build activity-based PSs, which stay inactive before getting activated by disease-associated stimuli. These activatable PSs dramatically improve the selectivity and efficacy of the therapy. In this review, we summarize small molecule and nanomaterial-based PDT and PTT agents that are activated selectively by H2S to initiate their cytotoxic effect. We incorporate single mode PDT and PTT agents along with synergistic and/or multimodal photosensitizers that can combine more than one therapeutic approach. Additionally, H2S-responsive theranostic agents, which offer therapy and imaging at the same time, are highlighted. Design approaches, working principles, and biological applications for each example are discussed in detail.

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Section: Phototherapymentioning

confidence: 99%

Section: Phototherapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hydrogen Sulfide Responsive Phototherapy Agents: Design Strategies and Biological Applications

Dirak

Turan

Kölemen

2023

ACS Bio Med Chem Au

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“…These linkers are tailored to respond to the tumor microenvironment, thiols, reactive oxygen species (ROS), acidic pH, and several enzymes that are overexpressed in the tumor cells, effectively serving as targeting units on their own. Theranostic agents featuring cleavable liners are termed activated theranostic prodrugs, as they usually suppress the imaging signal and/or cytotoxicity of the drug until activation occurs. , …”

Section: Nanoparticles Used For Theranostic Purposesmentioning

confidence: 99%

Nanomaterials as Theranostic Agents for Cancer Therapy

Bauri,

Tripathi,

Choudhury

et al. 2023

ACS Appl. Nano Mater.

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Photoresponsive Drug Delivery Systems: Challenges and Progress

Yang,

Long,

Chu

et al. 2024

Adv Funct Materials

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Photoresponsive drug delivery systems (PDDSs) have emerged as a promising toolbox for drug delivery, offering precise control over the site, duration, and dosage of light‐triggered medication. It allows controlled drug release, photo‐triggered targeting, diagnosis, and treatment, improving the precision and efficacy of therapies for various diseases. Despite progress in designing different PDDSs, clinical translation has been limited due to various obstacles. Herein, this review article focuses on three critical challenges of PDDSs: 1) accumulation at diseased lesions, 2) precision of light irradiation, and 3) penetration of light in tissues. Also, this article summarizes and discusses current advancements and strategies to address these challenges. Overall, it emphasizes the need to clarify the current challenges from bench to bedside and develop strategies to enhance therapeutic outcomes, increase compatibility and patient compliance, and unlock the possibilities in different clinical therapies.

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Small molecules as cancer targeting ligands: Shifting the paradigm

Cited by 29 publications

References 151 publications

Hydrogen Sulfide Responsive Phototherapy Agents: Design Strategies and Biological Applications

Hydrogen Sulfide Responsive Phototherapy Agents: Design Strategies and Biological Applications

Nanomaterials as Theranostic Agents for Cancer Therapy

Photoresponsive Drug Delivery Systems: Challenges and Progress

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