Abstract:WO 2020/035031 A1)Disease Area. Cancer Biological Target. RAS proteins (KRAS G12C mutant) Summary. Mitogen-activated protein kinases (MAPKs) are protein kinases that phosphorylate their own dual serine and threonine residues (autophosphorylation), or those found on their substrates, to activate or deactivate their target. The MAPK signaling pathway controls many essential cellular functions, such as aging and programmed cell death, calcium signaling, cytoskeleton organization, immune defense, cellular prolifer… Show more
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