Small-molecule fluorescence-based probes for interrogating major organ diseases

Abstract

This tutorial review describes recent advances involving small molecule fluorescent probes designed to aid in the study of major organ diseases.

Three birds with one stone: a single AIEgen for dual-organelle imaging, cell viability evaluation and photodynamic cancer cell ablation

“…Currently, many probes have been developed for the imaging of intracellular active substances and/or single/double organelles. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] However, because of the p-p stacking and other non-radiative pathways, conventional fluorophores often suffer from an aggregation-caused quenching (ACQ) effect, which might lead to weak fluorescence emission in the aggregation state and easy photobleaching. Fortunately, a new class of aggregation-induced emission (AIE) luminogens that was first proposed by Tang' group in 2001, 30 could perfectly solve the ACQ problems.…”

Fluorescent Chemosensors for Ion and Molecule Recognition: The Next Chapter

“…However, these reports inspired researchers to join the effort to develop fluorescent chemosensors for a wide variety of interdisciplinary and practical applications, of which we will now briefly highlight some of the most important trends. For detailed discussions on fluorescent chemosensor design and potential applications, we direct the reader to several excellent reviews (Wu et al, 2017;Sedgwick et al, 2018b;Wu et al, 2020;Feng et al, 2021;Han et al, 2021;Ma et al, 2021;Sedgwick et al, 2021a;Tian H. et al, 2021;Wu et al, 2021b).…”

“…Currently, researchers have access to a plethora of fluorescent chemosensors that allow for the detection of almost any diseasebased biomarker in vitro and in vivo. These chemosensors are regarded as chemical tools that can be employed to enhance our understanding of various pathological processes through the targeted visualization of key steps and biological intermediates (Han et al, 2021). Moreover, several technological advancements have led to the incorporation of fluorescent chemosensors into various sensor technologies that can provide meaningful qualityof-life improvements for consumers.…”

Recent Advances in Fluorescence Imaging of Pulmonary Fibrosis in Animal Models

“…Thanks to the advantages of high sensitivity, tunable specificity, controllable cost, acceptable biosafety, and noninvasiveness ( Fatahi et al, 2020 ; Guan et al, 2020 ; Niu et al, 2020 ; Guo et al, 2021 ; He et al, 2021 ), fluorescence imaging has been applied to visualize vascular system ( Ma et al, 2018 ; Zheng et al, 2019 ), lymphatic system ( Nakajima et al, 2018 ), various tumor tissues ( Bai et al, 2020 ; Bai et al, 2021 ), and real-time blood flow ( Hong et al, 2014 ; Wan et al, 2018 ; Cai et al, 2020 ). In addition, fluorescence imaging shows great potential in facilitating the development of precise therapeutic strategies for diseases, including imaging-guided cell therapy, drug delivery/release monitoring, and photodynamic therapy ( Li et al, 2020 ; Li et al, 2019a ; Liu et al, 2019 ; Han et al, 2021 ; Xu et al, 2021 ). It is clear that fluorescence imaging can play an important role in the diagnosis, treatment, and rehabilitation of PF.…”