Small molecule drug discovery for glioblastoma treatment based on bioinformatics and cheminformatics approaches
Liya Feng,
Sha Zhu,
Jian Ma
et al.
Abstract:Background: Glioblastoma (GBM) is a common and highly aggressive brain tumor with a poor prognosis for patients. It is urgently needed to identify potential small molecule drugs that specifically target key genes associated with GBM development and prognosis.Methods: Differentially expressed genes (DEGs) between GBM and normal tissues were obtained by data mining the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Gene function annotation was performed to investigate the potential f… Show more
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