Small molecule compound K-7174 attenuates neuropsychiatric manifestations in lupus-prone mice

Fan, Yuanyuan; Li, Xuan; Wu, Jinjin; Ni, Jiali; Liang, Jun; Hou, Yayi; Dou, Huan

doi:10.1016/j.brainres.2022.148203

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2023

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“…54 Similarly small molecule compounds such as K-7174 have shown to attenuate NPSLE manifestations in lupus-prone mice. 55 These again might hold promise for future treatments in NPSLE and SLE-TM.…”

Section: Future Perspectivesmentioning

confidence: 99%

Transverse myelitis associated with systemic lupus erythematosus (SLE-TM): A review article

Jain

Khormi

Sangle

et al. 2023

Lupus

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Systemic lupus erythematosus-related transverse myelitis (SLE-TM) is a rare but serious complication of SLE, which may result in significant morbidity. Its incidence is estimated between 0.5% and 1% of all SLE patients but may be the presenting feature in 30%–60% of these patients. Unfortunately, due to lack of high-quality studies, data regarding this condition remains limited. Its pathogenesis remains largely unknown and clinical presentation is variable. There are still no set guidelines regarding diagnosis, management, or monitoring and the role of autoantibodies remains controversial. In this review, we aim to summarize the available data regarding the epidemiology, pathogenesis, clinical features, management, and prognosis of this rare disease.

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Section: Future Perspectivesmentioning

confidence: 99%