Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein‐Protein Interaction
Robert Obermann,
Bereket Yemane,
Cassie Jarvis
et al.
Abstract:The DNA excision repair protein ERCC1 and the DNA damage sensor protein, XPA are highly overexpressed in patient samples of cisplatin‐resistant solid tumors including lung, bladder, ovarian, and testicular cancer. The repair of cisplatin‐DNA crosslinks is dependent upon nucleotide excision repair (NER) that is modulated by protein‐protein binding interactions of ERCC1, the endonuclease, XPF, and XPA. Thus, inhibition of their function is a potential therapeutic strategy for the selective sensitization of tumor… Show more
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