Small, low-cost implantable centrifugal pump for short-term circulatory assistance

Clark, Richard E.; Goldstein, Andrew H.; Pacella, John J.; Walters, Robert A.; Moeller, Frederick W.; Cattivera, Gina R.; Davis, Scott; Magovern, George J.

doi:10.1016/0003-4975(95)01018-1

Cited by 17 publications

(10 citation statements)

References 8 publications

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“…Although elevated pulmonary vascular resistance did not correlate with reduced pRVSD flow in this study, continuous-flow devices are known to be subject to the effects of increased afterload. 19 Contemporary algorithms for the management of RVF focus on reversing the underlying cause of RVF, maintaining adequate preload with volume resuscitation, reducing RV afterload with inhaled nitric oxide, and enhancing RV contractility with inotropes. In primary RV systolic dysfunction, maintaining low pulmonary vascular resistance, with or without augmenting RV contractility through inotropes, often provides adequate hemodynamic support.…”

Section: Discussionmentioning

confidence: 99%

Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure

Kapur

Paruchuri

Korabathina

et al. 2011

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure

Kapur

Paruchuri

Korabathina

et al. 2011

The Journal of Heart and Lung Transplantation

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“…The flow of centrifugal pumps 12,13 or axial pumps 14,15 used as LVADs is affected by the pressure gradient between inflow and outflow. Therefore, it is essential to maintain low or normal systemic vascular resistance for patients supported by these pumps.…”

Section: Discussionmentioning

confidence: 99%

Initial In Vivo Evaluation of the DexAide Right Ventricular Assist Device

et al. 2005

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Despite the increasing use of left ventricular assist devices for patients with end-stage congestive heart failure, no implantable, centrifugal right ventricular assist devices (RVADs) are available for those patients with significant right ventricular failure. The DexAide RVAD was developed to provide an implantable RVAD option to surgeons. The aim of this study was to evaluate pump performance in an acute in vivo model. The DexAide RVAD, developed as a modified CorAide left ventricular assist device, was implanted between the right ventricle and the pulmonary artery in four healthy calves. Pump speed was varied from 1800 rpm to 3600 rpm. RVAD performance was analyzed acutely at baseline and under conditions of low circulating volume, high contractility, high pulmonary arterial pressure, vasodilation, and low contractility. Pump flow was well maintained even under conditions of high pulmonary arterial pressure and vasodilation, with the exception of low circulating volume. Under all conditions, pulmonary arterial pressures were not affected by changing pump speed. The DexAide RVAD demonstrated acceptable hemodynamic characteristics for use as an implantable RVAD in the initial acute studies. Further studies are ongoing to examine the biocompatibility of the pump under chronic conditions.

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“…Acute heart failure, cardiogenic shock, cardiac surgery and rehabilitation are candidate diseases in the use of VADs. In the past decades, several VADs have being developed [3][4][5]. A specific design of VADs was recently reported by Sacristan et al which has been tested in vitro and in vivo with satisfactory hydrodynamic and hemodynamic results [5][6][7].…”

Section: Introductionmentioning

confidence: 97%

Structural Performance and Hydrodynamic Resistance of a New Silicone Auricular Cannula Tip

Tovar¹,

Escobedo²,

Rodríguez³

et al. 2006

2006 International Conference of the IEEE Engineering in Medicine and Biology Society

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Development of a new generation pneumatic of Ventricular Assist Device (VAD) required the design of cannulae to improve its optimal performance. In this case, a relevant restrictive design parameter was the material of the cannulae. Silicone was the best choice in a hemocompatible focus, but this is a material with very low stiffness. If the material is flexible, the most important parameter that affects either the structural performance or the hydrodynamic resistance is the amount of side holes on the cannulae tip, known as the effective drainage area. In order to obtain an estimation of the structural performance and of the hydrodynamic resistance, a study based on two independent analysis is needed: the structural and the in vitro drop pressure analysis. Structural analyses based on computer simulations were made in order to estimate the bending behavior of four silicone prototypes of cannulae tips. On the other hand, experiments under hydrostatic conditions were made to test and compare the pressure loss and flow rate relationship. A cannula tip with six side holes showed good hydrostatic performance, having almost the same as the one with nine side holes. Plus, it presented and a satisfactory structural behavior. This study assisted the design process of an auricular silicone cannula, recommending the use of cannulae with six side holes for a specific VAD.

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Small, low-cost implantable centrifugal pump for short-term circulatory assistance

Cited by 17 publications

References 8 publications

Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure

Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure

Initial In Vivo Evaluation of the DexAide Right Ventricular Assist Device

Structural Performance and Hydrodynamic Resistance of a New Silicone Auricular Cannula Tip

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