Small intestine mucosal adhesivity to in vivo capsule robot materials

Terry, Benjamin S.; Passernig, Anna C.; Hill, Morgan L.; Schoen, Jonathan A.; Rentschler, Mark E.

doi:10.1016/j.jmbbm.2012.06.018

Cited by 28 publications

(14 citation statements)

References 25 publications

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“…To this end, Terry et al investigated adhesive forces of different capsule robot materials (polycarbonate, stainless steel and micro patterned PDMS) against intestinal mucosa [81]. Mucoadhesion was evaluated using both tack and peel adhesion tests ex vivo.…”

Section: Macrodevices For Gi Manipulation (Mm Scale): Drug Deliverymentioning

confidence: 99%

Orally ingestible medical devices for gut engineering

Mandsberg

Christfort

Kamguyan

et al. 2020

Advanced Drug Delivery Reviews

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Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From micro-to macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers. Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions. We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. We have critically examined the relationship between materials-device design-pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future.

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Section: Macrodevices For Gi Manipulation (Mm Scale): Drug Deliverymentioning

confidence: 99%

Orally ingestible medical devices for gut engineering

Mandsberg

Christfort

Kamguyan

et al. 2020

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

show abstract

“…The duodenum and jejunum play major parts in digestion and absorption. The ileum is known as indigested and unabsorbed region [22]. The inner structure of the small intestine is the most complex, when compared with the other components of the GI tract.…”

Section: A Fundamental Knowledgementioning

confidence: 99%

“…c) Crawler mobility mechanism: The last type of friction force based mechanism is called crawler mobility which imitates a car or a tank to advance along the GI tract. Sliker et al [16], [22], [59] first proposed such preliminary capsule endoscopy driven by a DC micromotor. The DC motor leads a planetary gearbox to drive a worm set.…”

Section: A Fundamental Properties Of Locomotion Systemmentioning

confidence: 99%

A Review of Locomotion Systems for Capsule Endoscopy

Liu

Towfighian

Hila³

2015

IEEE Rev. Biomed. Eng.

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Wireless capsule endoscopy for gastrointestinal (GI) tract is a modern technology that has the potential to replace conventional endoscopy techniques. Capsule endoscopy is a pill-shaped device embedded with a camera, a coin battery, and a data transfer. Without a locomotion system, this capsule endoscopy can only passively travel inside the GI tract via natural peristalsis, thus causing several disadvantages such as inability to control and stop, and risk of capsule retention. Therefore, a locomotion system needs to be added to optimize the current capsule endoscopy. This review summarizes the state-of-the-art locomotion methods along with the desired locomotion features such as size, speed, power, and temperature and compares the properties of different methods. In addition, properties and motility mechanisms of the GI tract are described. The main purpose of this review is to understand the features of GI tract and diverse locomotion methods in order to create a future capsule endoscopy compatible with GI tract properties.

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“…As mentioned in (Terry et al 2012), the engineers designing active locomotion mechanisms for WCE would greatly benefit from having a quantitative measure of the propelling forces required to effectively move a capsule in the targeted GI segment. Several works have been published recently that address this scientific need.…”

Section: Introductionmentioning

confidence: 99%

“…The proposed methods to measure resistant properties of the GI tract range from ex vivo trials performed with benchtop equipment (Wang & Meng 2010, Kim et al 2006, Lyle et al 2013, Zhou et al 2013, to dedicated instrumentation that can acquire data in vivo during a surgical procedure (Samsom et al 1998, Terry et al 2012; however, the main limitation to all of the proposed methods thus far has been that a wired connection is always used to perform the measurement. In (Wang & Meng 2010), a capsule mockup sliding inside an intestinal lumen is pulled by a load cell through a string, whereas a multi-lumen connection is used in (Terry et al 2012) to operate the measurement device deployed in the small intestine of a living pig. Having a physical connection to the outside of the GI tract throughout the measurement has the potential to affect the readings and compromise the results integrity.…”

Section: Introductionmentioning

confidence: 99%

A wireless platform forin vivomeasurement of resistance properties of the gastrointestinal tract

et al. 2014

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Abstract. Active locomotion of wireless capsule endoscopes has the potential improve the diagnostic yield of this painless technique for the diagnosis of gastrointestinal tract disease. In order to design effective locomotion mechanisms, a quantitative measure of the propelling force required to effectively move a capsule inside the gastrointestinal tract is necessary.In this study, we introduce a novel wireless platform that is able to measure the force opposing capsule motion, without perturbing the physiologic conditions with physical connections to the outside of the gastrointestinal tract. The platform takes advantage of a wireless capsule that is magnetically coupled with an external permanent magnet. A secondary contribution of this manuscript is to present a real-time method to estimate the axial magnetic force acting on a wireless capsule manipulated by an external magnetic field. In addition to the intermagnetic force, the platform provides real-time measurements of the capsule position, velocity, and acceleration.The platform was assessed with benchtop trials within a workspace that extends 15 cm from each side of the external permanent magnet, showing average error in estimating the force and the position of less than 0.1 N and 10 mm, respectively. The platform was also able to estimate the dynamic behavior of a known resistant force with an error of 5.45%. Finally, an in vivo experiment on a porcine colon model validated the feasibility of measuring the resistant force in opposition to magnetic propulsion of a wireless capsule.

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Small intestine mucosal adhesivity to in vivo capsule robot materials

Cited by 28 publications

References 25 publications

Orally ingestible medical devices for gut engineering

Orally ingestible medical devices for gut engineering

A Review of Locomotion Systems for Capsule Endoscopy

A wireless platform forin vivomeasurement of resistance properties of the gastrointestinal tract

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