Small Intestine Bacterial Overgrowth

King, Charles; Toskes, Phillip P.

doi:10.1016/s0016-5085(79)91337-4

Cited by 310 publications

(86 citation statements)

References 156 publications

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“…Indeed, proximal deconjugation of bile salts usually does not modify their fecal excretion, but can lead to fat malabsorption and diarrhea. This clinical feature is well known during chronic bacterial colonisation of the small bowel [62]. In healthy ileostomists we observed that ingested LAB (Btfidobacterium sp.…”

Section: Potential Hypocholesterolemic Actions?mentioning

confidence: 65%

Potential of using lactic acid bacteria for therapy and immunomodulation in man

Marteau¹

1993

FEMS Microbiology Reviews

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There is in 1993 no proven medical indication of lactic acid bacteria (LAB) for therapy or immunomodulation in man. However, within the bulk of publications, rigorous trials have now opened rational fields of research on beneficial effects of LAB. These include lactose digestion, cholesterol metabolism, diarrheal disorders, prophylaxis of intestinal or urogenital infections, immunomodulation or even oral vaccination. We try here to analyse these studies, considering LAB as pharmacological agents, and conclude that pursuit of research could be promising for ecological therapy of mucosal diseases, and for development of original and flexible vectors for targeting in the gastrointestinal tract.

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Section: Potential Hypocholesterolemic Actions?mentioning

confidence: 65%

Potential of using lactic acid bacteria for therapy and immunomodulation in man

Marteau¹

1993

FEMS Microbiology Reviews

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“…The overgrowth of enteric bacteria, especially potentially pathogenic aerobes, alters the anatomic and physiological barrier function of the intestinal mucosa, and might eventually result in invasion of enteric bacteria to extra-intestinal sites or the systemic circulation [23-263. Furthermore, bacterial overgrowth can result in the production of endotoxin in the intestinal lumen [27]. Intraperitoneal implantation of rubber drain pieces together with injection of E. coli resulted in a significant increase in cecal population levels of anaerobic bacteria, in addition to a more pronounced increase in the number of the enteric microflora might account for bacterial translocation.…”

Section: Discussionmentioning

confidence: 99%

Abdominal rubber drain piece aggravates intra‐abdominal sepsis in the rat

Guo

Soltesz

Ding

et al. 1994

Eur J Clin Investigation

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Biomaterials in the peritoneal cavity disrupt the physiology of the host and may cause bacterial translocation. The current study was performed to determine whether biomaterials exacerbate intra-abdominal infections. Adult male rats were divided into four groups: group 1, celiotomy+intraperitoneal (i.p.) saline; group 2, celiotomy+i.p. Escherichia coli (3 x 10(8) cfu); group 3, i.p. rubber+i.p. saline; and group 4, i.p. rubber+i.p. E. coli (3 x 10(8) cfu). Twelve h after the challenge, enteric bacterial translocation, bacterial population levels in the cecum and serum levels of IL-6 and TNF were measured. Bacterial translocation to mesenteric lymph nodes and the liver was observed in animals from groups 2 and 3, but significantly increased in group 4 with a concomitant elevation of serum levels of TNF and IL-6, as compared with group 1. Histological examination revealed a more pronounced inflammatory reaction in the peritoneum and distal ileum in group 4 than in groups 2 and 3. These results suggest that the presence of rubbers in the peritoneal cavity aggravates intra-abdominal sepsis.

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“…Morbidity following ileal resection may be due to loss of the important and unique absorptive capabilities of the ileum and continuous seeding of the stomach and upper gastrointestinal tract with caecal or colon contents subsequent to loss of the ileocaecal valve (King and Toskes 1979;Banwell 1981). In man, removal of the ileum initially leads to profuse diarrhoea, the passage of bile acids and fats in the faeces (Chen 1969).…”

Section: Discussionmentioning

confidence: 99%

“…The stomach and cranial small intestine is normally low in bacterial counts (IO4-105 CFU/ml), which increase toward the ileum. Alterations in the bacterial counts of the cranial small intestine have been associated with a clinical syndrome of nutrient malabsorption, weight loss and malnutrition (King and Toskes 1979;Banwell 1981) and may occur with loss of the ileocaecal valve. Jejuno/ileal bypass is also associated with liver dysfunction (Vanderhoof, Tuma, Antonson and Sorrel1 1982).…”

Section: Discussionmentioning

confidence: 99%

A preliminary study on the effects of jejunocaecostomy in horses

Bertone

Stashak

Ralston

et al. 1992

Equine Veterinary Journal

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Summary Ileal bypass by re‐section and jejunocaecostomy is a commonly performed surgery in horses, but has a reportedly lower success rate than other small intestinal surgeries. Lower success rates and chronic problems with diarrhoea, weight loss, protein, sugar and fat malabsorption, and Ca/P imbalance occur in man. The purpose of this study was to investigate changes in bodyweight, nutrient digestion and absorption, and serum and urine composition in horses before and 3, 12 and 27 weeks after ileal resection and side‐to‐side jejunocaecostomy. Four adult, healthy horses had a baseline CBC; serum creatinine, cholesterol, Na, K, Cl, Mg, Ca, P; digestion trial; xylose and fat absorption test; and serum total bile acid test. Digestion of dry matter, crude protein, total plant cell wall, cellulose, hemicellulose, and lignin; and urinary fractional excretions of Na, K, Cl, P and Ca were calculated. A one‐way analysis of variance compared baseline values to those obtained after caeliotomy and jejunocaecostomy (P<0.05). Results include a significant decrease in serum calcium and total protein 27 weeks after surgery and a significant increase in FENa, FECa, and faecal metabolic organic matter 27 weeks after surgery. Bodyweight decreased significantly 3 weeks after surgery, but increased to greater than baseline values at 12 and 27 weeks after surgery. Vitamin A absorption curves were normal (sigmoid) before surgery and linear at all times after surgery. Serum cholesterol was significantly lower 27 weeks after surgery and a trend (P<0.1) for a lower serum cholesterol was observed 3 weeks after surgery. No significant differences were apparent in serum electrolytes, faecal water, protein or fibre digestibility, xylose absorption or serum bile acid measurements. In summary, ileal bypass affected the horses minimally, but derangements of Ca metabolism, fat (fat soluble vitamin) absorption and microbial flora need further study.

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Small Intestine Bacterial Overgrowth

Cited by 310 publications

References 156 publications

Potential of using lactic acid bacteria for therapy and immunomodulation in man

Potential of using lactic acid bacteria for therapy and immunomodulation in man

Abdominal rubber drain piece aggravates intra‐abdominal sepsis in the rat

A preliminary study on the effects of jejunocaecostomy in horses

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