Small-Intestinal Transit Time in the Elderly

Haboubi, N.Y.; Hudson, Peter; Rahman, Quazi Mehbubar; Lee, G.S.; Ross, Allen G.

doi:10.1016/s0140-6736(88)91732-1

Cited by 17 publications

(3 citation statements)

References 2 publications

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“…The intraindividual variation of both locus was represented by a segment of the gut distal from the first locus. Since the transit time of a liquid the absolute bioavailability and these absorption variables was improved by administering strontium in meal through the small intestine was estimated at 1.2 h to 1.9 h [25], the lag times obtained for the second combination with a meal instead of during fasting parameters at later time points are dominated by…”

Section: Discussionmentioning

confidence: 99%

“…At the start of each test, blood was sampled for serum calcium, albumin, alkaline phosphafollowed were in accordance with the Declaration of Helsinki. The subjects were in good physical condition tase, c-GT, creatinine, parathyroid hormone (PTH), 25 was collected into heparinized tubes and centrifuged at 1500 g for 10 min. Subsequently, plasma was separated and stored at −20°C until analysis.…”

Section: Introductionmentioning

confidence: 99%

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Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility

Sips¹,

Vijgh

Barto

et al. 1996

Brit J Clinical Pharma

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1 The absorption kinetics of orally administered strontium chloride and its reproducibility were investigated in healthy volunteers after administering strontium either under fasting conditions (study I, n=8) or in combination with a standardized meal (study II, n=8). Each subject received strontium orally at day 0, 14, and 28 and intravenously at day 42. The study was performed as part of a project in which a simple clinical test for measuring intestinal calcium absorption is being developed, based on the use of stable strontium as a marker. 2 Plasma strontium concentration-time curves were analysed by noncompartment analysis and a four compartment disposition model. Within a volunteer each oral curve was fitted simultaneously with the intravenous curve, by which means a two segment model for absorption was revealed. 3 Mean absolute bioavailability of strontium was 25% without a meal and 19% with a meal, whereas the intraindividual variation was 24% and 20%, respectively. 4 Various limited sampling absorption parameters were determined in order to select a potential test parameter for measuring intestinal calcium absorption using strontium as a marker. Fractional absorption at 4 h (Fc 240 ), obtained after co-ingestion of strontium with a meal, appeared to be the best test parameter, because it represented bioavailability well (r=0.90 ).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility

Sips¹,

Vijgh

Barto

et al. 1996

Brit J Clinical Pharma

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“…13 Crossstudy comparisons of total GI transit or orocecal transit across various age groups of healthy subjects including children (neonates included), adults, and the elderly are summarized in Table 1. [12][13][14][15][16][17][18] Upon further examining the results reported by Brogna et al, 14 though the elderly adults (on average, 75 years of age) and younger adults (on average, 30 years old) had similar total GI transit times as shown in Table 1, they had a significantly slower gastric emptying of radiopaque markers (2 Â 5 mm 2 ) taken with a meal, than younger adults. From the group of children averaging 5.5 years old (2 months to 12 years old) studied by Corazziari et al 15 ( Table 1), further analysis by dividing the children into two different age groups of 2-3 years old group and 3-12 years old group revealed no difference in the total GI transit time between these two groups.…”

Section: Impact Of Agementioning

confidence: 99%

Literature Review of Gastrointestinal Physiology in the Elderly, in Pediatric Patients, and in Patients with Gastrointestinal Diseases

Bai

Burckart

Mulberg

2016

Journal of Pharmaceutical Sciences

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Oral bioavailability studies during the development of new medical entities or generic drugs are typically performed in healthy volunteers. Approved drug products are, however, used by patients with diverse disease backgrounds, and by pediatric and elderly patients. To provide the knowledge base for assessing the potential effects of age or co-morbidity on the in vivo performance of an orally absorbed, systemically active drug product, the literature regarding the gastrointestinal (GI) physiological characteristics (pH, permeability, and transit time) in children, in the elderly, and in patients with GI diseases (irritable bowel syndrome, ulcerative colitis, and Crohn's disease) is reviewed herein, with the knowledge gaps highlighted.

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The Gastrointestinal Tract

Holt

1995

Comprehensive Physiology

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The sections in this article are: Salivary Glands Stomach Gastric Secretion Small Intestine Morphology Brush Border Membranes Enzymes Intestinal Permeability Protein Synthesis Intestinal Absorption Gut‐Associated Immune System Splanchnic Blood Flow Gastrointestinal Motility Esophagus Stomach Neuromuscular Functioning Colon and Rectum Pancreas Liver and Biliary Tree Morphology Age‐Associated Effects Consequences of Aging Bile Gastrointestinal Hormones Cellular Proliferation Esophagus and Stomach Small Intestine Colon Effects of Caloric Restriction

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Small-Intestinal Transit Time in the Elderly

Cited by 17 publications

References 2 publications

Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility

Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility

Literature Review of Gastrointestinal Physiology in the Elderly, in Pediatric Patients, and in Patients with Gastrointestinal Diseases

The Gastrointestinal Tract

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