Small intestinal submucosa as a superior vena cava graft in the dog

Lantz, Gary C.; Badylak, Stephen F.; Coffey, Arthur C.; Geddes, L. A.; Sandusky, George E.

doi:10.1016/0022-4804(92)90031-t

Cited by 141 publications

(84 citation statements)

References 15 publications

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“…As such, SIS is a resorbable biomaterial, and it has been used successfully as a xenogenic tissue graft that induces constructive remodeling of a variety of animal tissues, including blood vessels, urinary bladder, dura, abdominal wall, tendons, and ligaments. [16][17][18][20][21][22][23][24][25][26] Indeed, numerous studies have demonstrated that following implantation, SIS fosters rapid host tissue ingrowth and progressive remodeling of the regenerated tissue into a site-specific functional tissue. 19 The results of this study confirm those of previous investigations and demonstrate, in a canine model, that SIS can be used as a xenogenic biomaterial to regenerate large connective tissue defects and prevent the formation of nonspecific scar tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Through angiogenesis and host cells migration and differentiation, the regenerative process results in a tissue that is structurally and functionally Correspondence to: L. M. Dejardin: e-mail: Dejardin@ cvm.msu.edu similar to the original tissue. Indeed, SIS xenografts successfully have been used in canine models experimentally to regenerate various tissues, such as blood vessels, [16][17][18] urinary bladder wall defects, 20,21 dural defects, 22 abdominal wall defects, 23,24 tendons, 25 and ligaments. 26 The purpose of this study was to determine the efficacy of a SIS implant with respect to the regeneration of large connective tissue defects using a fascia lata defect model in the dog.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Use of small intestinal submucosal implants for regeneration of large fascial defects: An experimental study in dogs

Déjardin

Arnoczky

Clarke

1999

J. Biomed. Mater. Res.

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A single layer of porcine small intestinal submucosa (SIS) was sutured into a 5 x 5 cm window created in the fascia lata of ten adult mongrel dogs in order to determine the efficacy of this material in promoting tissue regeneration of large fascial defects. A similar defect in the contralateral limb was left empty and served as a negative control. Tissue regeneration was examined grossly and histologically at 6 and 12 weeks. By 6 weeks, marked fibroplasia and angiogenesis had occurred throughout the SIS scaffold. The regenerated tissue was well organized and showed good integration with the adjacent fascia while the control specimens were filled with loose areolar connective tissue. At 12 weeks the experimental defects were filled with a regenerated tissue that grossly and histologically resembled normal fascia. There was no evidence of adhesions to the underlying musculature. Conversely, the tissue that filled the control defects remained disorganized and was markedly thinner than the adjacent fascia. The results of this study suggest that SIS is capable of supporting tissue regeneration in large fascial defects. The ability of this material to induce regeneration of a substantial area of tissue grossly and histologically similar to normal fascia and without adhesions to the underlying musculature makes its application in reconstructive surgery appear promising.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of small intestinal submucosal implants for regeneration of large fascial defects: An experimental study in dogs

Déjardin

Arnoczky

Clarke

1999

J. Biomed. Mater. Res.

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“…It seems that, if tissue-engineered blood vessels are to be a viable and durable vascular conduit in vivo, a confluent endothelium is an important prerequisite. Previous non-endothelialized implants of decellularized biological conduits in animal models produced moderately acceptable patency rates when placed in sites of either high flow or low resistance, or both 15,19,20,22,23 . In one animal study 21 , small intestinal submucosa was implanted as a small-diameter vascular graft in high-flow anastomoses involving carotid and femoral arteries; all animals received warfarin and aspirin for up to 8 weeks after surgery.…”

Section: Thromboresistance and Endothelializationmentioning

confidence: 99%

Tissue engineering of vascular conduits

Yow

Ingram

Korossis

et al. 2006

British Journal of Surgery

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In vitro and in vivo approaches are currently being used for guided cell repopulation of both biological and synthetic scaffolds. The major clinical problem has been extended culture time (approximately 6 weeks), which precludes their use in the acute setting. However, recent advances have led not only to improved patency rates for prostheses, but also to a potential reduction in culture time. In addition, increased mobilization of endothelial progenitor cells in the presence of ischaemic tissue may increase the autologous cell yield for scaffold reseeding with further reduction in culture time.

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“…14,15 This result was recognized by Lantz and colleagues, who first used SIS in animal studies as a vascular patch, where it demonstrated tissue-specific regeneration in both arteries and veins. 16,17 Kropp and colleagues subsequently demonstrated, in both small and large animal models, that SIS alone can promote bladder regeneration when used as an unseeded graft. Histological evaluation demonstrated that the serosal, muscle and mucosal layers of the bladder wall had undergone regeneration.…”

Section: Unseeded Technologymentioning

confidence: 99%

Tissue engineering in urology

Matoka

Cheng

2013

CUAJ

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Tissue engineering encompasses a multidisciplinary approach geared toward the development of biological substitutes designed to restore and maintain normal function in diseased or injured tissues. This article reviews the basic technology that is used to generate implantable tissue-engineered grafts in vitro that will exhibit characteristics in vivo consistent with the physiology and function of the equivalent healthy tissue. We also examine the current trends in tissue engineering designed to tailor scaffold construction, promote angiogenesis and identify an optimal seeded cell source. Finally, we describe several currently applied therapeutic modalities that use a tissue-engineered construct. While notable progress has clearly been demonstrated in this emerging field, these efforts have not yet translated into widespread clinical applicability. With continued development and innovation, there is optimism that the tremendous potential of this field will be realized.Can Urol Assoc J 2009;3(5):403-8 Résumé L'ingénierie tissulaire englobe une approche multidisciplinaire axée sur le développement de substituts biologiques en vue de rétablir et de maintenir la fonction normale de tissus lésés. L'article qui suit passe en revue la technologie fondamentale utilisée pour générer des greffons implantables produits par ingénierie in vitro et possédant des caractéristiques in vivo correspondant aux tissus sains équivalents sur les plans physiologique et fonctionnel. Nous examinons également les tendances actuelles en ingénierie tissulaire visant à adapter des échafaudages tissulaires, à promouvoir l'angiogenèse et à dégager une source optimale de cellules implantables. Enfin, nous décrivons plusieurs modalités thérapeu-tiques actuellement mises en application utilisant un échafaudage créé par ingénierie tissulaire. En dépit de progrès remarquables dans ce domaine en effervescence, les efforts déployés ne se sont pas encore traduits par une applicabilité clinique étendue. Des développements et des percées continus permettent d'être optimiste face au potentiel prodigieux de ce domaine.

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Small intestinal submucosa as a superior vena cava graft in the dog

Cited by 141 publications

References 15 publications

Use of small intestinal submucosal implants for regeneration of large fascial defects: An experimental study in dogs

Use of small intestinal submucosal implants for regeneration of large fascial defects: An experimental study in dogs

Tissue engineering of vascular conduits

Tissue engineering in urology

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