Small intestinal mucosal immunity and morphometry in luminal overgrowth of indigenous gut flora

Riordan, Stephen M.; McIver, Christopher J.; Wakefield, Denis; Duncombe, V. M.; Thomas, M.; Bolin, T. D.

doi:10.1016/s0002-9270(00)02326-1

Cited by 16 publications

(18 citation statements)

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“…However, the microbial signatures of small bowel in health and disease are not well‐established due to the difficulty of sampling, especially for the distal segment. Consequently, the duodenal flora is commonly used as a “gold standard” for the diagnosis of SIBO, which considered to partially represent the proximal small intestinal microbiota . It may be hard to identify the mild SIBO with excessive bacteria only in the distal small bowel without proximal invasion.…”

Section: Discussionmentioning

confidence: 99%

Duodenal and rectal mucosal microbiota related to small intestinal bacterial overgrowth in diarrhea‐predominant irritable bowel syndrome

Yang

Zhang

Hong

et al. 2019

J of Gastro and Hepatol

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Key wordsglucose hydrogen breath test, irritable bowel syndrome, microbial dysbiosis index, mucosalassociated microbiota, small intestinal bacterial overgrowth. AbstractBackground and Aim: Small intestinal bacterial overgrowth (SIBO) has been proposed as an etiologic factor in irritable bowel syndrome, particularly the diarrhea-predominant subtype (IBS-D). We aimed to identify potential intestinal microbial pattern in IBS-D patients with SIBO. Methods: Diarrhea-predominant irritable bowel syndrome patients fulfilling Rome III criteria were recruited and randomly divided into an exploratory cohort (57 cases) and a validation cohort (20 cases). SIBO was identified according to standard glucose hydrogen breath test. For 16S rRNA gene sequencing, samples of duodenal mucosa, duodenal fluid, rectal mucosa, and fresh feces were collected and performed. The α and β diversity, as well as differences in microbial composition and function, in SIBO + and SIBO À IBS-D subjects were evaluated. Results: The microbial diversity and composition obviously differed between SIBO + and SIBO À IBS-D in duodenal and rectal mucosa but not in duodenal fluid and fresh feces. For rectal mucosal microbiota, it displayed markedly reduced aerobe and Gram-negative bacteria and increased facultative anaerobe and Gram-positive bacteria, moreover, altered functions of microbial metabolism in SIBO + IBS-D. Significantly higher rectal mucosarelated microbial dysbiosis index was observed in SIBO + IBS-D, and a cut-off value at À0.37 had a sensitivity of 56.55% and specificity of 90.91% to identify the SIBO in IBS-D subjects. Conclusions: Mucosal microbiota, rather than luminal bacteria, has a more apparent dysbiosis in SIBO + IBS-D patients relative to those without SIBO. Rectal mucosaassociated microbiota may act as a potential predictor of SIBO in IBS-D patients.

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Section: Discussionmentioning

confidence: 99%

Duodenal and rectal mucosal microbiota related to small intestinal bacterial overgrowth in diarrhea‐predominant irritable bowel syndrome

Yang

Zhang

Hong

et al. 2019

J of Gastro and Hepatol

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“…Small intestinal bacterial overgrowth is frequently associated with GI symptoms such as bloating, distension, flatulence, abdominal discomfort, diarrhoea and weight loss and may even cause structural changes such as atrophy of small intestinal villi with subsequent alterations of small intestinal absorption. SIBO symptoms overlap with those of IBD, often making it unclear if it is the cause, consequence or an epiphenomenon in relation to the other disorder.…”

Section: Introductionmentioning

confidence: 99%

Systematic review with meta‐analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease

Shah

Morrison

Burger

et al. 2019

Aliment Pharmacol Ther

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Background: Current data on small intestinal bacterial overgrowth (SIBO) in patients with inflammatory bowel diseases (IBD) are controversial.Aim: To conduct a systematic review and meta-analysis to determine the prevalence of SIBO in patients with ulcerative colitis (UC) and Crohn's disease (CD). Methods: Electronic databases were searched up to May 2018 for studies reporting prevalence of SIBO in IBD patients. The prevalence rate of SIBO among IBD patients and the odds ratio (OR) and 95% CI of SIBO in IBD patients compared with controls were calculated. Results: The final dataset included 11 studies (1175 adult patients with IBD and 407 controls), all utilising breath test for diagnosis of SIBO. The proportion of SIBO in IBD patients was 22.3% (95% CI 19.92-24.68). The OR for SIBO in IBD patients was 9.51 (95% CI 3.39-26.68) compared to non-IBD controls, and high in both CD (OR = 10.86; 95% CI 2.76-42.69) and UC (OR = 7.96; 95% CI 1.66-38.35). In patients with CD, subgroup analysis showed the presence of fibrostenosing disease (OR = 7.47; 95% CI 2.51-22.20) and prior bowel surgery (OR = 2.38; 95% CI 1.65-3.44), especially resection of the ileocecal valve, increased the odds of SIBO. Individual studies suggest that combined small and large bowel disease but not disease activity may be associated with SIBO. Conclusions: Overall, there is a substantial increase in the prevalence of SIBO in IBD patients compared to controls. Prior surgery and the presence of fibrostenosing disease are risk factors for SIBO in IBD. Additional supporting information will be found online in the Supporting Information section at the end of the article. How to cite this article: Shah A, Morrison M, Burger D, et al. Systematic review with meta-analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease.

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“…A few retrospective studies have identified the causes of LD, which include coeliac disease, 9, 10 gastrointestinal infections, 11, 12 immunological disorders, 9, 13 nonsteroidal anti‐inflammatory drugs (NSAID), 9, 14 inflammatory bowel disease (IBD), 15 IgA deficiency 16 and more recently Helicobacter pylori 17, 18 . Vande Voort et al.…”

Section: Introductionmentioning

confidence: 99%

A prospective study into the aetiology of lymphocytic duodenosis

Aziz

Evans

Hopper

et al. 2010

Aliment Pharmacol Ther

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Small intestinal mucosal immunity and morphometry in luminal overgrowth of indigenous gut flora

Cited by 16 publications

References 0 publications

Duodenal and rectal mucosal microbiota related to small intestinal bacterial overgrowth in diarrhea‐predominant irritable bowel syndrome

Duodenal and rectal mucosal microbiota related to small intestinal bacterial overgrowth in diarrhea‐predominant irritable bowel syndrome

Systematic review with meta‐analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease

A prospective study into the aetiology of lymphocytic duodenosis

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