Small intestinal motility disorders

Ghoshal, Uday C

doi:10.1016/b978-0-12-813037-7.00022-4

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…38,42 Vasodilators have been used to treat GI disorders by enhancing smooth muscle relaxation. 2 It is hypothesized that TENS may cause an increase in blood flow and allows for the release of neuropeptides. 49 Zhang et al 49 found that TENS increases local blood flow in the treated area in their animal study, which likely contributes to its mechanism of action.…”

Section: Mechanis Ms Of Ac Tionmentioning

confidence: 99%

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Transcutaneous electrical stimulation for gastrointestinal motility disorders

Song,

Trujillo,

et al. 2023

Neurogastroenterology Motil

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Background/PurposeGastrointestinal (GI) dysmotility is categorized by muscle or nerve dysfunctions in any portion of the GI tract, which leads to abnormalities in GI motor and sensory function. Symptoms may vary depending on the organ affected and can be debilitating. Treatment usually involves diet and lifestyle changes. Pharmacotherapy is limited in effectiveness with various side effects. Transcutaneous electrical stimulation (TES), a noninvasive, needleless technique that provides electrical stimulation using cutaneous non‐needle electrodes, has become increasingly popular. It has been shown to be beneficial in treating GI motility disorders.MethodsThis review paper navigates through the different TES techniques, including transcutaneous peripheral nerve (vagal/sacral/tibial nerves) electrical stimulation, transcutaneous electrical acustimulation (stimulation via acupuncture point), transcutaneous interferential current therapy, and transcutaneous electrical nerve stimulation.Key ResultsAs we delve deeper, we explore the promising effects of TES on dysphagia, gastroesophageal reflux disease, functional dyspepsia, gastroparesis, postoperative ileus, constipation, and irritable bowel syndrome. The literature at hand speaks volumes about the therapeutic prowess of this noninvasive technique.Conclusion & InferencesThe time is ripe to evaluate further the full therapeutic potential of TES, a noninvasive, nonpharmaceutical, nonsurgical, and home‐based self‐administrative technique in managing GI motility disorders.

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Section: Mechanis Ms Of Ac Tionmentioning

confidence: 99%

“…2 Therapy is mainly focused on diet and lifestyle modification, and pharmacotherapies are limited in effectiveness with various side effects. 2…”

mentioning

confidence: 99%

Transcutaneous electrical stimulation for gastrointestinal motility disorders

Song,

Trujillo,

et al. 2023

Neurogastroenterology Motil

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“…MMCs serve the role of housekeepers propelling desquamated cells, microbes, and residual food through the GI tract. Impaired MMC activity may cause retention of the luminal contents, resulting in diseases associated with gastroparesis, intestinal pseudo‐obstruction, and small intestinal bacterial overgrowth (Ghoshal, 2020). Ingestion of food will immediately interrupt the MMCs, with a return to peristalsis (Du et al., 2018).…”

Section: Characteristics Of the Gastric And Small Intestinal Motilitymentioning

confidence: 99%

Simulating human gastrointestinal motility in dynamic in vitro models

Kong

2022

Comp Rev Food Sci Food Safe

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The application of dynamic in vitro gastrointestinal (GI) models has grown in popularity to understand the impact of food structure and composition on human health. Given that GI motility is integral to digestion and absorption, a predictive in vitro model should faithfully replicate the motility patterns and motor functions in vivo. In this review, typical characteristics of gastric and small intestinal motility in humans as well as the biomechanical and hydrodynamic events pertinent to gut motility are summarized. The simulation of GI motility in the presently existing dynamic in vitro models is discussed from an engineering perspective and categorized into hydraulic, piston/probe‐driven, roller‐driven, pneumatic, and other systems. Each system and its representative models are evaluated in terms of their motility patterns, the key hydrodynamic characteristics concerning gut motility, their performance in simulating the key physiological events, and their ability to establish in vitro–in vivo correlations. Practical Application: The review paper provided useful information in the design of dynamic GI models and the simulation of human gastric and small intestinal motility which are important for understanding food and health.

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“…The drug improves gastric motility disorders [32], promotes emptying of gastric contents, comforts the acid reflux, and dyspepsia symptoms [33], and has an anti-emetic effect [34]. Clinically the recommended dose of ITP HCL is 50 mg [35], the method of ITP HCL was also determined on RP-HPLC [36].…”

Section: Introductionmentioning

confidence: 99%

Method development and validation for simultaneous determination of Eletriptan hydrobromide and Itopride hydrochloride from fast dissolving buccal films by using RP-HPLC

Siddique

Sarfraz

Zaman

et al. 2023

AChrom

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One of the most effective, rapid, and simple methods reversed-phase high-performance liquid chromatography (RP-HPLC) was used for simultaneous development and validation of Eletriptan hydrobromide (ELE HBR) and Itopride hydrochloride (ITP HCL) in combination. The method was validated based on the regulations of United States Pharmacopeia (USP) and International Conference on Harmonization (ICH) guidelines. Separation of both drugs was achieved within approximately 5 min by using a mobile phase made up of a 70:30 ratio of phosphate buffer and acetonitrile having a flow rate of 1 mL min−1. Furthermore, a comprehensive study was conducted on precision, accuracy, linearity, inter-day, intra-day studies, an assay of formulated films, and stability studies of combined prepared film. Co-efficient of correlation ranged between 0.9993, and 0.9965 for ELE HBR and ITP HCL respectively. The accuracy of the developed method was accurate as drug recoveries in both cases of ITP HCL, and ELE HBR falls between (99.87, 99.96, and 99.84%) to (99.81, 99.12, and 98.44%) respectively having a concentration range of solutions between 10, 30 and 50 μg mL−1 dilution. Films developed by using both drugs in combination were then validated for assay studies, and it was found that substantial results of 99.05%, and 99.87% were found in the case of ITP HCL and ELE HBR respectively. The stability of the solution and mobile phase showed the method's accuracy as the results were 97% for ITP HCL and 99% for ELE HBR. The proposed method developed for simultaneous determination of ITP HCL and ELE HBR was developed and validation and no interaction of any excipient were found.

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Small intestinal motility disorders

Cited by 3 publications

References 33 publications

Transcutaneous electrical stimulation for gastrointestinal motility disorders

Transcutaneous electrical stimulation for gastrointestinal motility disorders

Simulating human gastrointestinal motility in dynamic in vitro models

Method development and validation for simultaneous determination of Eletriptan hydrobromide and Itopride hydrochloride from fast dissolving buccal films by using RP-HPLC

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