Small Intestinal Biopsy in a Patient with Crohn's Disease of the Duodenum

Schuffler, Michael D.; Chaffee, Robert G.

doi:10.1016/s0016-5085(79)91334-9

Cited by 31 publications

(2 citation statements)

References 14 publications

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“…Other histological features, such as erosions in both stomach and duodenum and "cryptitis" and villous atrophy in the duodenum, may also be suggestive of CD (7,18), but our numbers of patients were too small to establish such a relationship. Erosions and cryptitis have also been shown to correlate with granulomas (7).…”

Section: Histology Versus Endoscopymentioning

confidence: 90%

Endoscopic and Histologic Findings in the Upper Gastrointestinal Tract of Children with Crohn's Disease

Schmidt‐Sommerfeld,

Kirschner,

Stephens

1990

J. pediatr. gastroenterol. nutr.

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In an attempt to define endoscopic and histologic changes suggestive of upper gastrointestinal Crohn's disease (CD), the medical histories, endoscopic reports, and biopsies were reviewed from 24 pediatric patients with CD and 28 age‐matched patients without CD in whom esophagogastroduodenoscopies were performed because of upper GI symptoms. No differences in the overall frequency of endoscopic abnormalities were found between the two groups. However, gastric erosions and ulcerations were more frequent in CD patients. Histological abnormalities in the stomach and duodenum were also more frequent in CD patients. Noncaseating granulomas were found in five patients with CD and in one patient without clinical, radiologic, or endoscopic evidence of CD. Focal inflammation in the stomach and duodenum occurred more frequently in CD patients. Two patients with CD had focal and deep chronic inflammatory infiltrates in the esophagus, which reached the submucosa. Abnormal histology was often seen in CD patients with normal endoscopic appearances. We conclude that superficial ulcerations seen during endoscopy and the histological finding of focal inflammation may represent upper GI CD in pediatric patients. Histological changes can be missed if biopsies are not taken from normal‐appearing mucosa during endoscopy.

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Section: Histology Versus Endoscopymentioning

confidence: 90%

Endoscopic and Histologic Findings in the Upper Gastrointestinal Tract of Children with Crohn's Disease

Schmidt‐Sommerfeld,

Kirschner,

Stephens

1990

J. pediatr. gastroenterol. nutr.

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“…In contrast Otto and Gebers (5), in an electron microscopic study, reported a marked neutrophil infiltration in Crohn's disease, particularly in the ileal region, and it is considered that neutrophils are present in, and are characteristic of, Crohu's disease of the proximal small intestine (6,7). Other evidence for the importance of neutrophils in Crohn's disease has come from the study of Kane, Hoffbrand, and Neale (8), which suggested an increased neutrophil pool and turnover, and from Saverymuttu et al (9), who showed a large migration of neutrophils to the gut using lIlIn-labelled leucocytes.…”

Section: Introductionmentioning

confidence: 97%

Polymorphonuclear Neutrophil Leucocytes in Childhood Crohn's Disease

Lewis,

Walker‐Smith,

Phillips

1987

J. pediatr. gastroenterol. nutr.

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SummaryLight and electron microscopy was applied to surgical resections and endoscopic biopsies from the ileum and colon of 15 children with Crohn's disease in order to investigate the involvement of neutrophils in the disease process. Clear evidence was found of neutrophil infiltration of the lamina propria and epithelium, neutrophil migration into the gut lumen through epithelial breaks and intact epithelium, neutrophil phagocytosis of luminal and lamina propria bacteria, and the presence of intracellular neutrophils in enterocytes. Similar findings were seen in 5 of 6 children with ulcerative colitis and in a case of an E. coli colitis, but not in 8 controls. The observations demonstrate the involvement of neutrophils in Crohn's disease in childhood and suggest that the response is directed, in part, against luminal enterobacteria and enterocytes.

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The Abnormal Biopsy

DobbinsIII

1990

Diagnostic Pathology of the Intestinal Mucosa

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Small Intestinal Biopsy in a Patient with Crohn's Disease of the Duodenum

Cited by 31 publications

References 14 publications

Endoscopic and Histologic Findings in the Upper Gastrointestinal Tract of Children with Crohn's Disease

Endoscopic and Histologic Findings in the Upper Gastrointestinal Tract of Children with Crohn's Disease

Polymorphonuclear Neutrophil Leucocytes in Childhood Crohn's Disease

The Abnormal Biopsy

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