Small intestinal bacterial overgrowth is associated with Diarrhea-predominant irritable bowel syndrome by increasing mainly <i>Prevotella</i> abundance

Wu, Kangqi; Sun, Wenjing; Li, Ning; Chen, Yuqin; Wei, Yanling; Chen, Dongfeng

doi:10.1080/00365521.2019.1694067

Cited by 24 publications

(26 citation statements)

References 30 publications

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“…Slightly higher rates of SIBO were seen in studies that utilized breath testing as opposed to small intestinal aspiration ( (17). Figure 1 summarizes the prevalence of SIBO in IBS vs controls from case-control studies (n>80) using Rome III and the latest Rome IV criteria for IBS (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Our analysis of these 13 studies shows that the pooled SIBO rate is significantly higher in IBS subjects than in controls (30 vs 9%, n = 2,494, p < 0.0001).…”

Section: Prevalence Of Sibo In Ibsmentioning

confidence: 99%

“…Overall SIBO is highly prevalent in IBS. *Used Rome IV definition, all other studies used Rome III (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

Section: Prevalence Of Sibo In Ibsmentioning

confidence: 99%

“…The association between SIBO and IBS seemed to be the strongest for IBS-D vs IBS-C or IBS-M, at 35.5% (95% CI 32.7–40.3) vs 22.5% (95% CI 18.1–26.9) or 25.2% (95% CI 22.2–28.4), respectively. Since this meta-analysis, one study utilizing the newer Rome IV diagnostic criteria for IBS has shown that the prevalence of SIBO is increased in subjects with IBS (51.7 vs. 16.7%, p ≤ .001) ( 17 ). Figure 1 summarizes the prevalence of SIBO in IBS vs controls from case-control studies (n>80) using Rome III and the latest Rome IV criteria for IBS ( 17 – 29 ).…”

Section: Prevalence Of Sibo In Ibsmentioning

confidence: 99%

“…Since this meta-analysis, one study utilizing the newer Rome IV diagnostic criteria for IBS has shown that the prevalence of SIBO is increased in subjects with IBS (51.7 vs. 16.7%, p ≤ .001) ( 17 ). Figure 1 summarizes the prevalence of SIBO in IBS vs controls from case-control studies (n>80) using Rome III and the latest Rome IV criteria for IBS ( 17 – 29 ). Our analysis of these 13 studies shows that the pooled SIBO rate is significantly higher in IBS subjects than in controls (30 vs 9%, n = 2,494, p < 0.0001).…”

Section: Prevalence Of Sibo In Ibsmentioning

confidence: 99%

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Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update

Takakura

Pimentel

2020

Front. Psychiatry

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Small intestinal bacterial overgrowth (SIBO) is one manifestation of gut microbiome dysbiosis and is highly prevalent in IBS (Irritable Bowel Syndrome). SIBO can be diagnosed either by a small bowel aspirate culture showing ≥10 3 colony-forming units (CFU) per mL of aspirate, or a positive hydrogen lactulose or glucose breath test. Numerous pathogenic organisms have been shown to be increased in subjects with SIBO and IBS, including but not limited to Enterococcus, Escherichia coli, and Klebsiella. In addition, Methanobrevibacter smithii, the causal organism in a positive methane breath test, has been linked to constipation predominant irritable bowel syndrome (IBS-C). As M. smithii is an archaeon and can overgrow in areas outside of the small intestine, it was recently proposed that the term intestinal methanogen overgrowth (IMO) is more appropriate for the overgrowth of these organisms. Due to gut microbiome dysbiosis, patients with IBS may have increased intestinal permeability, dysmotility, chronic inflammation, autoimmunity, decreased absorption of bile salts, and even altered enteral and central neuronal activity. As a consequence, SIBO and IBS share a myriad of symptoms including abdominal pain, distention, diarrhea, and bloating. Furthermore, gut microbiome dysbiosis may be associated with select neuropsychological symptoms, although more research is needed to confirm this connection. This review will focus on the role of the gut microbiome and SIBO in IBS, as well as novel innovations that may help better characterize intestinal overgrowth and microbial dysbiosis.

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Section: Prevalence Of Sibo In Ibsmentioning

confidence: 99%

“…Overall SIBO is highly prevalent in IBS. *Used Rome IV definition, all other studies used Rome III (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

Section: Prevalence Of Sibo In Ibsmentioning

confidence: 99%

Section: Prevalence Of Sibo In Ibsmentioning

confidence: 99%

Section: Prevalence Of Sibo In Ibsmentioning

confidence: 99%

See 2 more Smart Citations

Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update

Takakura

Pimentel

2020

Front. Psychiatry

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“…All participants have signed informed consent. The diagnosis of SIBO was established as previously reported, by a combination of typical clinical and histological criteria [15,16]. All enrolled patients had moderate to severe SIBO based on the result of LHBT.…”

Section: Recruitment Of Patients and Donors Patientsmentioning

confidence: 99%

Clinical efficacy of fecal microbiota transplantation for patients with small intestinal bacterial overgrowth: a randomized, placebo-controlled clinic study

Wang

Xing

et al. 2021

BMC Gastroenterol

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Background Small intestinal bacterial overgrowth (SIBO) is characterized by the condition that bacteria overgrowth in the small intestine. Fecal microbiota transplantation (FMT) has been applied as an effective tool for reestablishing the structure of gut microbiota. However, whether FMT could be applied as a routine SIBO treatment has not been investigated. Methods In this trial, 55 SIBO patients were enrolled. All participants were randomized in two groups, and were given FMT capsule or placebo capsules once a week for 4 consecutive weeks. Measurements including the lactulose hydrogen breath test gastrointestinal symptoms, as well as fecal microbiota diversity were assessed before and after FMT therapy. Results Gastrointestinal symptoms significantly improved in SIBO patients after treatment with FMT compared to participants in placebo group. The gut microbiota diversity of FMT group had a significant increase, while placebo group showed none. Conclusions This study suggests that applying FMT for patients with SIBO can alleviate gastrointestinal symptoms, indicating that FMT may be a promising and novel therapeutic regimen for SIBO. Trial registry This study was retrospectively registered with the Chinese Clinical Trial registry on 2019.7.10 (ID: ChiCTR1900024409, http://www.chictr.org.cn).

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The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth

et al. 2021

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Background: Small intestinal bacterial overgrowth treatment is usually based on antibiotics with no guidelines available.Objective: This study aimed to investigate the efficacy of different antibiotics to treat small intestinal bacterial overgrowth.Methods: Consecutive patients referred to our tertiary center and diagnosed with intestinal bacterial overgrowth were retrospectively included. Patients were diagnosed using a 75 g glucose breath test. Patients were treated either with a single antibiotic (quinolone or azole) or rotating antibiotics (quinolone and azole, one after the other) for 10 consecutive days per month for 3 months. A negative glucose breath test after antibiotic treatment was considered as remission. Quality of life (GIQLI) and gastrointestinal severity (IBS-SSS) were assessed before and after antibiotic treatment. Symptomatic evaluation was realized in simple blind of glucose breath test result: patients were unaware of their results.Results: Between August 2005 and February 2020, 223 patients were included in the analysis (female 79.8%, mean age 50.2 ± 15.7 years). Remission was observed in 119 patients (53.4%) after one course of antibiotics and was more frequent in patients receiving rotating antibiotics than in patients receiving a single antibiotic (70.0% vs. 50.8%, p = 0.050). Remission was associated with a significant improvement in quality of life (p = 0.035) and in bloating (p = 0.004). Conclusion:In this study, the treatment of small intestinal bacterial overgrowth using rotating antibiotics was more effective than treatment using a single course of antibiotic. Remission was associated with improvement in both quality of life and bloating.

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Small intestinal bacterial overgrowth is associated with Diarrhea-predominant irritable bowel syndrome by increasing mainly Prevotella abundance

Cited by 24 publications

References 30 publications

Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update

Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update

Clinical efficacy of fecal microbiota transplantation for patients with small intestinal bacterial overgrowth: a randomized, placebo-controlled clinic study

The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth

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