Small intestinal bacterial overgrowth is common after gastrectomy but with little impact on nutritional status

Aisa, Angeles Pérez; Gavilán, Mari Carmen García; García, J. Alcaide; Sánchez, I.M. Méndez; Irigoin, Robin Rivera; Cano, F.M. Fernández; Salguero, Teresa Pereda; Rivas-Ruiz, Francisco

doi:10.1016/j.gastre.2019.01.007

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…First, we used historical controls. However, the positivity for GBT in controls has already been validated in our previous studies ( 5 – 7 , 12 ). Second, it should be considered that this study was conducted in Korea, which has a prevalence of Helicobacter pylori of more than 40%.…”

Section: Discussionmentioning

confidence: 52%

“…The suggested pathophysiologic mechanism of SIBO might be impaired intestinal motility after a hysterectomy, which is a well-known major cause of adhesions in the small intestine ( 20 ). The high prevalence of SIBO in patients who have undergone gastrectomy has been reported, ranging from 15% to 83% ( 5 – 7 , 12 ). In this study, the prevalence of GBT+ in the gastrectomy group was significantly higher than that in the other 2 surgical groups, which was consistent with the results of another recent study ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

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Serum Gastrin Predicts Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Patients With Abdominal Surgery: A Prospective Study

Kim

Paik

et al. 2020

Clin Transl Gastroenterol

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OBJECTIVES: Small intestinal bacterial overgrowth (SIBO) might be associated with a history of abdominal surgery. We aimed to evaluate the prevalence of SIBO and to investigate serum gastrin and pepsinogen as predictors of SIBO in patients with a history of hysterectomy, gastrectomy, or cholecystectomy. METHODS: This prospective study surveyed 146 patients with a history of hysterectomy, gastrectomy, or cholecystectomy, and 30 healthy controls, who underwent a hydrogen (H 2 )-methane (CH 4 ) glucose breath test (GBT) for SIBO. Serum pepsinogen I and II and gastrin levels were reviewed. RESULTS: GBT positivity (+) was significantly higher in patients with histories of abdominal surgery than that in in controls (37.6% vs 13.3%, P < 0.01). Among GBT+ patients, 36.0% (18/50), 96.2% (25/26), and 17.1% (12/70) were in the hysterectomy, gastrectomy, and cholecystectomy groups, respectively. Among the GBT subtypes, 43.6% (24/55), 10.9% (6/55), and 45.5% (25/55) of patients were in the GBT(H 2 )+, GBT(CH 4 )+, and GBT(mixed)+ groups, respectively. The gastrectomy group had significantly more GBT+ or GBT(H 2 )+ patients than the other surgical groups. Gastrin levels were higher in GBT(H 2 )+ patients and lower in GBT(CH 4 )+ patients than those in GBT− patients. Previous gastrectomy and elevated gastrin levels were independent predictive factors of GBT(H 2 )+. DISCUSSION: SIBO is not uncommon in patients with histories of abdominal surgeries, but it is more common in patients who have undergone gastrectomy. Serum gastrin level could be a serologic predictor of H 2 -producing SIBO. The relationship between serum gastrin and SIBO requires further research.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Serum Gastrin Predicts Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Patients With Abdominal Surgery: A Prospective Study

Kim

Paik

et al. 2020

Clin Transl Gastroenterol

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“…We can define SIBO (small intestine bacterial overgrowth) by the abnormal and excessive presence of bacteria in the small intestine that are normally found in the large intestine [2,9]. This requires diagnostic tests such as small bowel aspirate/culture with growth of 10 3-10 5 CFU/ml, which is accepted as the "best diagnostic method" (S:100 and E:100); the disadvantage is that it is invasive, expensive and requires an expert gastroenterologist to perform; and the glucose (S:6-93% and E:78-100%) or lactulose (S:6-68% and E:44-70%) breath test which is a safe and non-invasive diagnostic method to diagnose IBS patients [9][10][11][12]. In the intestine there are four main sources of gas, mainly hydrogen (H2), carbon dioxide (CO2) and methane (CH4).…”

Section: Resultsmentioning

confidence: 99%

"Syndrome and Bacterial Overgrowth in the Small Intestine"

Zampayo

2023

BJSTR

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The present work analyzes the most frequent cause of consultation in Gastroenterology services worldwide, Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by recurrent symptoms that include abdominal pain and abnormal bowel habits either in the form of diarrhea, constipation, or both; in the absence of an apparent organic cause, with a global prevalence estimated at 11.2% with predominance in women, the prevalence of Latin America seems to be higher than that reported internationally if Rome II is considered (24.4%), and if the publications that used Rome III are considered, the prevalence was 11.8%.

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“…Patients are often accompanied by symptoms such as diarrhoea, bloating, abdominal discomfort, and abdominal pain, referred to as SIBO (Small intestinal bacterial overgrowth) [17]. In the Pérez Aisa et al study, SIBO was found in 61.6% of patients after gastrectomy [20].…”

Section: Nutritional Problems Of Patients After Gastrectomymentioning

confidence: 99%

Nutritional problems of patients after gastrectomy and the risk of developing malnutrition

Grochowska,

Gazi,

Surwiłło-Snarska

et al. 2024

Nowotwory. Journal of Oncology

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The radical treatment for advanced gastric cancer is gastrectomy. This procedure disrupts the anatomy and physiology of the gastrointestinal tract. After surgery, nausea, heartburn, biliary regurgitation, feeling of early satiety, belching, lack of appetite, and swallowing problems are reported to affect food intake.Decreased absorption, loss of nutrients, and increased energy requirements of cancer patients lead to weight loss and the development of malnutrition. After gastrectomy, the composition of the intestinal microbiome changes, the exocrine activity of the pancreas decreases, and deficiency-metabolic disorders (including iron, vitamin B 12 , zinc, and vitamin D) develop. Approximately 60-70% of gastrectomy patients experience clinically significant deterioration in quality of life. Nutritional management should include dietary modification, appropriate nutritional supplementation and close monitoring of the nutritional status of these patients.

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Small intestinal bacterial overgrowth is common after gastrectomy but with little impact on nutritional status

Cited by 4 publications

References 21 publications

Serum Gastrin Predicts Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Patients With Abdominal Surgery: A Prospective Study

Serum Gastrin Predicts Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Patients With Abdominal Surgery: A Prospective Study

"Syndrome and Bacterial Overgrowth in the Small Intestine"

Nutritional problems of patients after gastrectomy and the risk of developing malnutrition

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