Small hospitals matter: insights from the emergence and spread of vancomycin-resistant enterococci in 2 public hospitals in inner Brazil

Corrêa, André Luis; Pignatari, Antônio Carlos Campos; Silveira, Mônica da; Mingone, Roberta Cristina Cabral; Oliveira, Vinicius Gomes de Sales; Fortaleza, Carlos Magno Castelo Branco

doi:10.1016/j.diagmicrobio.2015.03.026

Cited by 10 publications

(3 citation statements)

References 23 publications

(19 reference statements)

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“…They showed that the application of third generation cephalosporins, metronidazole and fluorquinolones may lead to an increased VRE rate in hospitals. Correa et al (2015) conducted a study on risk factors for the emergence and spread of VRE in two hospitals in inner Brazil. Besides mechanical ventilation, the use of broad-spectrum antimicrobials was determined as the main risk factor for VRE acquisition.…”

Section: Discussionmentioning

confidence: 99%

Outbreaks caused by vancomycin-resistant Enterococcus faecium in hematology and oncology departments: A systematic review

Ulrich

Vonberg

Gastmeier

2017

Heliyon

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BackgroundVancomycin-resistance in Enterococcus faecium (VRE) poses a major threat in health care settings. It is well known that patients in hematology and oncology departments are especially at risk of nosocomial VRE acquisition. This systematic review of the literature provides data on the main sources, transmission modes and potential risk factors for VRE acquisition as well as appropriate infection control measures in order to terminate such nosocomial outbreaks.MethodsData on nosocomial VRE outbreaks on hematology and oncology wards was retrieved from the Outbreak Database and PubMed.ResultsA total of 35 VRE outbreaks describing 757 affected patients and 77 deaths were included in this review. The most frequent site of pathogen detection were stool samples or rectal swabs (57% of all isolation sites), followed by blood cultures (30%). The most common outbreak source was an index patient. The main modes of transmission were 1) hands of health care workers, 2) contact to a contaminated environment and 3) patient-to-patient contact. The most common risk factor for VRE positivity was prior antibiotic treatment. The most common infection control measures performed were screening and isolating or cohorting of patients.ConclusionA rational use of antibiotics in hematology and oncology units is recommended in order to reduce selection pressure on resistant pathogens such as VRE. In addition the importance of hand hygiene should be stressed to all staff whenever possible.

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Section: Discussionmentioning

confidence: 99%

Outbreaks caused by vancomycin-resistant Enterococcus faecium in hematology and oncology departments: A systematic review

Ulrich

Vonberg

Gastmeier

2017

Heliyon

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“…Even though, Correa et al found that multi-drug resistance can be a problem even in small hospitals. 23 …”

Section: Discussionmentioning

confidence: 99%

Total antibiotic use in a state-wide area and resistance patterns in Brazilian hospitals: an ecologic study

Boszczowski

Neto

Blangiardo

et al. 2020

The Brazilian Journal of Infectious Diseases

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“…Studies from different countries have reported different risk factors for vancomycin-resistant Enterococci (VRE) infection, including comorbidities (liver disease, diabetes, and central nervous system disease), medical procedures (surgery), and antibiotic usage [19]. The aim of this study was to understand the characteristics of VRE infection of the urinary tract and analyse the risk factors for VRE infection to strengthen infection control and decrease the spread of VRE in the hospital environments.…”

Section: Introductionmentioning

confidence: 99%

Trends and Risk Factors for Healthcare-Associated Vancomycin-Resistant Enterococci of Urinary Tract Infections in Taiwan

Cheng

Lin

et al. 2023

Preprint

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Purpose: Vancomycin can be used to treat many bacterial infections, although the generation of vancomycin-resistant Enterococci (VRE) may cause adverse consequences. We analysed the trends and the risk factors for healthcare-associated urinary tract infections (UTIs) by VRE. Methods: This retrospective study included patients who were hospitalized from 2009–2015 and had hospital-acquired enterococci infections who fulfilled the Centers for Disease Control and Ministry of Health and Welfare criteria, as determined by infection control professionals. Results: The mean age of the 594 participants was 72.3 years. The proportion of men with enterococcal UTIs was 70%. The proportion of VRE infections among all enterococcal UTIs was lowest in 2009 (18.1%) and highest in 2015 (47.3%). An increasing trend in the proportion of patients with VRE UTIs was observed from 2009–2015. Length of hospitalization of more than 40 days, placement of double-lumen catheters, and placement of a nasogastric tube were associated with a higher risk of VRE in UTIs (odds ratio=1.93–2.72, all P <.05). Conclusions: The use of unnecessary invasive catheters in patients with double-lumen catheters or nasogastric tubes should be reduced. Environmental disinfection and hand hygiene should be implemented.

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Small hospitals matter: insights from the emergence and spread of vancomycin-resistant enterococci in 2 public hospitals in inner Brazil

Cited by 10 publications

References 23 publications

Outbreaks caused by vancomycin-resistant Enterococcus faecium in hematology and oncology departments: A systematic review

Outbreaks caused by vancomycin-resistant Enterococcus faecium in hematology and oncology departments: A systematic review

Total antibiotic use in a state-wide area and resistance patterns in Brazilian hospitals: an ecologic study

Trends and Risk Factors for Healthcare-Associated Vancomycin-Resistant Enterococci of Urinary Tract Infections in Taiwan

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