Small Hepatocellular Carcinoma: Relationship of Signal Intensity to Histopathologic Findings and Metal Content of the Tumor and Surrounding Hepatic Parenchyma

Ebara, Masaaki; Fukuda, Hiroyuki; Kojima, Yohei; Morimoto, Naoki; Yoshikawa, Masaharu; Sugiura, Norío; Satoh, Tsunenobu; Kondo, Fukuo; Yukawa, Masae; Matsumoto, Takeshi; Saisho, Hiromitsu

doi:10.1148/radiology.210.1.r99ja4181

Cited by 122 publications

(82 citation statements)

References 20 publications

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“…Reduction in the intracellular Zn and increase in Cu have been reported in association with chronic liver diseases by Hatano et al 11) ; an increase in the Cu content in a small HCC by Ebara et al 17) In hepatocytes, it is believed that Cu exists mainly as Cu,Zn-SOD, Cu,Zn-MT and Cu-MT. 9,10) It is likely that Cu, which increases in advanced chronic hepatitis and small HCC, exists in one of these forms.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography (HPLC)

Kubo

Fukuda

Ebara

et al. 2005

Biological & Pharmaceutical Bulletin

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Metallothionein (MT) was initially discovered from a horse kidney in 1957 as a protein that contained cadmium. Metallothionein is a heat-stable, metal-binding protein with a molecular weight of 6500 to 7000. 1) A number of physiological and biological roles have been suggested for MT, including detoxification of heavy metals, metabolic regulation of Zinc (Zn) and Copper (Cu) (two trace elements that are essential to the body), and a radical-scavenging action that is closely related to the biological defense mechanism.

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Section: Discussionmentioning

confidence: 93%

Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography (HPLC)

Kubo

Fukuda

Ebara

et al. 2005

Biological & Pharmaceutical Bulletin

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“…Finally, the incremental value of mild-moderate T2 hyperintensity for the diagnosis of HCC is modest, as most HCCs with this feature are progressed lesions that can be detected based on vascular or hepatobiliary phase imaging features. As a corollary, mildmoderate T2 hyperintensity suggests advanced tumor grade and so may have prognostic significance (136,139).…”

Section: Ancillary Features That Favor the Diagnosis Of Malignancy Bumentioning

confidence: 99%

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

Choi¹,

Lee²,

Sirlin³

2014

Radiology

451

385

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Computed tomography (CT) and magnetic resonance (MR) imaging play critical roles in the diagnosis and staging of hepatocellular carcinoma (HCC). The second article of this two-part review discusses basic concepts of diagnosis and staging, reviews the diagnostic performance of CT and MR imaging with extracellular contrast agents and of MR imaging with hepatobiliary contrast agents, and examines in depth the major and ancillary imaging features used in the diagnosis and characterization of HCC.q RSNA, 2014

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“…Previous reports of the relationship between magnetic resonance imaging (MRI) signal intensity and the histological differentiation of HCCs [22][23][24] indicate that well differentiated and moderately/poorly differentiated HCCs can be distinguished based on MRI signal intensity. Typical moderately/poorly differentiated HCCs show hypointensity on T1-weighted imaging and hyperintensity on T2-weighted imaging [25].…”

Section: Introductionmentioning

confidence: 99%

Assessment of hepatocellular carcinomas using conventional magnetic resonance imaging correlated with histological differentiation and a serum marker of poor prognosis

et al. 2011

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Purpose To establish a method of assessing the malignant potential of hepatocellular carcinoma (HCC) using magnetic resonance imaging (MRI). Methods For 69 nodules [12 Edmondson (Ed)-I, 48 Ed-II, 9 Ed-III] in 54 HCC patients, signal intensity patterns and enhancement patterns of gadopentate dimeglumine (Gd-DTPA) dynamic studies were correlated with histological differentiation and serum lens culinaris agglutinin-reactive alpha-fetoprotein (AFP-L3) level, which is an indicator of poor prognosis. Results Hypointensity on T1-weighted imaging was seen in 17, 72, and 89% of Ed-I, Ed-II, and Ed-III HCCs, respectively (P \ 0.001). Meanwhile, hyperintensity on T2-weighted imaging was seen in 42, 88, and 89% (P \ 0.005). Tumor stain during the arterial phase of Gd dynamic MRI was seen in 75, 86, and 89%. Tumor stain washout during the portal phase was seen in 43% of Ed-II and 100% of Ed-III HCCs (P \ 0.005). In the Ed-II and Ed-III HCCs, hypointensity on T1-weighted imaging was seen in 65% of AFP-L3-negative HCCs and 90% of AFP-L3-positive HCCs (P = 0.071). Washout of tumor stain during the portal phase was seen in 39% of AFP-L3-negative HCCs and 75% of AFP-L3-positive HCCs (P \ 0.05). Conclusions Although hyperintensity of tumor on T2-weighted imaging and arterial hypervascularity of tumor are considered to be useful for differential diagnosis between well differentiated HCCs and moderately/poorly differentiated HCCs, hypointensity of tumor on T1-weighted imaging and tumor stain washout during the portal phase of Gd-DTPA dynamic MRI reflected poorer histological differentiation of HCCs and correlated with AFP-L3 levels.

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Small Hepatocellular Carcinoma: Relationship of Signal Intensity to Histopathologic Findings and Metal Content of the Tumor and Surrounding Hepatic Parenchyma

Cited by 122 publications

References 20 publications

Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography (HPLC)

Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography (HPLC)

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

Assessment of hepatocellular carcinomas using conventional magnetic resonance imaging correlated with histological differentiation and a serum marker of poor prognosis

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