Small G protein signaling modulator 3 (SGSM3) knockdown attenuates apoptosis and cardiogenic differentiation in rat mesenchymal stem cells exposed to hypoxia

Jung, Seung Eun; Choi, Jung-Won; Moon, Hanbyeol; Oh, Sena; Lim, Soyeon; Lee, Seahyoung; Kim, Sang Woo

doi:10.1371/journal.pone.0231272

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Cardiogenesis and embryonic heart progression rely heavily on Notch/Jagged1 signaling ( Li et al., 2006 ), which is activated by HGF/c-Met signaling. In short, it has been indicated that Wnt signaling has a huge impact on MSCs differentiation into cardiac cell lineages ( Li et al., 2006 ; Huang et al., 2013 ; Jung et al., 2020 ). Wnt signaling is triggered through the coupling of the Frizzled family receptors ( Komiya and Habas, 2008 ).…”

Section: Mscs Differentiation Into Cardiomyocytesmentioning

confidence: 99%

Mechanotransduction of mesenchymal stem cells (MSCs) during cardiomyocytes differentiation

Raman

Imran²,

Noordin³

et al. 2022

Heliyon

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Section: Mscs Differentiation Into Cardiomyocytesmentioning

confidence: 99%

Mechanotransduction of mesenchymal stem cells (MSCs) during cardiomyocytes differentiation

Raman

Imran²,

Noordin³

et al. 2022

Heliyon

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A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling

Mehrabipour

Jasemi

Dvorský

et al. 2023

Cells

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SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of protein complexes through physical interactions with a pool of proline-rich/noncanonical motifs from partner proteins. They are widely studied modular building blocks across all five kingdoms of life and viruses, mediating various biological processes. The SH3 domains are also implicated in the development of human diseases, such as cancer, leukemia, osteoporosis, Alzheimer’s disease, and various infections. A database search of the human proteome reveals the existence of 298 SH3 domains in 221 SH3 domain-containing proteins (SH3DCPs), ranging from 13 to 720 kilodaltons. A phylogenetic analysis of human SH3DCPs based on their multi-domain architecture seems to be the most practical way to classify them functionally, with regard to various physiological pathways. This review further summarizes the achievements made in the classification of SH3 domain functions, their binding specificity, and their significance for various diseases when exploiting SH3 protein modular interactions as drug targets.

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Mechanotransduction in Mesenchymal Stem Cells (MSCs) Differentiation: A Review

Raman

Imran

Noordin

et al. 2022

IJMS

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Mechanotransduction is the process by which physical force is converted into a biochemical signal that is used in development and physiology; meanwhile, it is intended for the ability of cells to sense and respond to mechanical forces by activating intracellular signals transduction pathways and the relative phenotypic adaptation. It encompasses the role of mechanical stimuli for developmental, morphological characteristics, and biological processes in different organs; the response of cells to mechanically induced force is now also emerging as a major determinant of disease. Due to fluid shear stress caused by blood flowing tangentially across the lumen surface, cells of the cardiovascular system are typically exposed to a variety of mechanotransduction. In the body, tissues are continuously exposed to physical forces ranging from compression to strain, which is caused by fluid pressure and compressive forces. Only lately, though, has the importance of how forces shape stem cell differentiation into lineage-committed cells and how mechanical forces can cause or exacerbate disease besides organizing cells into tissues been acknowledged. Mesenchymal stem cells (MSCs) are potent mediators of cardiac repair which can secret a large array of soluble factors that have been shown to play a huge role in tissue repair. Differentiation of MSCs is required to regulate mechanical factors such as fluid shear stress, mechanical strain, and the rigidity of the extracellular matrix through various signaling pathways for their use in regenerative medicine. In the present review, we highlighted mechanical influences on the differentiation of MSCs and the general factors involved in MSCs differentiation. The purpose of this study is to demonstrate the progress that has been achieved in understanding how MSCs perceive and react to their mechanical environment, as well as to highlight areas where more research has been performed in previous studies to fill in the gaps.

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Small G protein signaling modulator 3 (SGSM3) knockdown attenuates apoptosis and cardiogenic differentiation in rat mesenchymal stem cells exposed to hypoxia

Cited by 3 publications

References 52 publications

Mechanotransduction of mesenchymal stem cells (MSCs) during cardiomyocytes differentiation

Mechanotransduction of mesenchymal stem cells (MSCs) during cardiomyocytes differentiation

A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling

Mechanotransduction in Mesenchymal Stem Cells (MSCs) Differentiation: A Review

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