Small fibre integrity and axonal pathology in the rat model of experimental autoimmune neuritis
Pia Renk,
Melissa Sgodzai,
Rafael Klimas
et al.
Abstract:Experimental autoimmune neuritis (EAN) is a common animal model for acute human immune-mediated polyneuropathies. Although already established in 1955, a number of pathophysiological mechanisms still remain unknown. Here, we extensively characterize EAN progression in Lewis rats, including new insights into the integrity of small nerve fibers, neuropathic pain, and macrophage activation. Acute EAN was induced with P253-78 peptide and consequently investigated using the gait analysis system CatWalk XT, electrop… Show more
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