Small-Dose Propofol by Continuous Infusion Does Not Prevent Postoperative Vomiting in Females Undergoing Outpatient Laparoscopy

Effects of propofol on ipecacuanha‐induced nausea and vomiting

“…Our study clearly demonstrated that ondansetron blocks the effects of ipecacuanha and the volunteers started to experience nausea after the ondansetron infusion was stopped. In a study by Scuderi et al, the same dose of propofol as in our study given postoperatively to females after outpatient laparoscopy did not prevent nausea and vomiting (16). TramPr et al, comparing propofol and other anesthetics, demonstrated in a meta-analysis that propofol has only minimal effects in reducing PONV (17), and it has also been shown that only one out of five patients with established PONV, treated with ondansetron, does not experience further nausea and vomiting (18).…”

Combining propofol with morphine in patient-controlled analgesia to prevent postoperative nausea and vomiting

“…17 Postoperative infusions of propofol have been tried as prophylaxis against PONV, with conflicting results. [8][9][10][11] Patients in the study by Ewalenko and colleagues 8 received an infusion of propofol started in recovery after thyroid surgery. The incidence of PONV was reduced from 65% (in the control group) to 10%, 8 but patients in two other studies did not benefit from using propofol in this way.…”

“…The incidence of PONV was reduced from 65% (in the control group) to 10%, 8 but patients in two other studies did not benefit from using propofol in this way. 9 10 In these three studies, [8][9][10] propofol was not used for anaesthesia, although Scudieri and colleagues 10 started the subhypnotic infusion of propofol before anaesthesia and surgery. Modest success has been reported in reducing the severity of PONV after intrathecal morphine using a postoperative infusion of propofol for 24 h. 11 Our premise when starting this study was that by coupling the dose of propofol to that of morphine and by using boluses, which have been shown to be effective, propofol with morphine in a PCA may be an effective technique for both analgesia and antiemesis.…”

“…[5][6][7][8] Small doses of propofol given in recovery were successful in treating PONV, 7 but the results with postoperative infusion for 24-48 h after surgery were conflicting. [8][9][10][11] We have studied the effects of simultaneous administration of propofol and morphine patient-controlled analgesia (PCA) on the incidence of PONV.…”

Antiemetische Wirkung von Propofol

“…Keinen Unterschied in der PONVInzidenz fanden auch Splinter et al [47] nach Im Gegensatz zu diesen Arbeiten konnten Scuderi et al [44] in einer PONV-Präventionsstudie diese guten Ergebnisse nicht bestätigen. 60 Frauen mit ambulant durchzuführenden Laparoskopien wurden randomisiert und in doppelblinder Art ab 30 min vor Anäs-thesieeinleitung, entweder mit einem Bolus von Propofol 0,1 mg/kg und anschließender kontinuierlicher Infusion von Propofol 1 mg·kg-1 ·h -1 , oder mit einer äquivalenten Menge von Intralipid® 10%, bis zur Entlassung aus dem Aufwachraum behandelt.…”