Small-dose emulsion treatment of ragweed pollinosis. A double-blind study continued for three seasons

A Review of Immunotherapy

“…Mineral oil is a more effective immunologic adjuvant than alum in animal work. Trials in humans were reported enthusiastically at first (7, 13, 38) but controlled trials showed at best modest efficacy (3,10,11,19,48,59). Local nodules and sterile abscesses were a problem; moreover, mineral oil is not metabolized and retnains in the tissues indefinitely.…”