Small-diameter vascular grafts of Bombyx mori silk fibroin prepared by a combination of electrospinning and sponge coating

Sato, Michiko; Nakazawa, Yasumoto; Takahashi, R.; Tanaka, Kimie; Sata, Masataka; Aytemiz, Derya; Asakura, Tetsuo

doi:10.1016/j.matlet.2010.05.024

Cited by 41 publications

(34 citation statements)

References 10 publications

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“…This scaffold promoted SMC modulation into a contractile phenotype and supported their survival and biological function. The electrospun silk fibronin grafts coated with silk sponge [52] have also been utilized for vascular graft applications. A recent report on small-diameter polyurethane (PU) graft [53] is also noteworthy.…”

Section: Application Of Electrospun Scaffolds In Tissue Engineerinmentioning

confidence: 99%

Electrospun scaffolds for tissue engineering of vascular grafts

et al. 2014

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There is a growing demand for off-the-shelf tissue engineered vascular grafts (TEVGs) for replacement or bypass of damaged arteries in various cardiovascular diseases. Scaffolds from the decellularized tissue skeletons to biopolymers and biodegradable synthetic polymers have been used for fabricating TEVGs. However, several issues have not yet been resolved, which include the inability to mimic the mechanical properties of native tissues, and the ability for long term patency and growth required for in vivo function. Electrospinning is a popular technique for the production of scaffolds that has the potential to address these issues. However, its application to human TEVGs has not yet been achieved. This review provides an overview of tubular scaffolds that have been prepared by electrospinning with potential for TEVG applications.

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Section: Application Of Electrospun Scaffolds In Tissue Engineerinmentioning

confidence: 99%

Electrospun scaffolds for tissue engineering of vascular grafts

et al. 2014

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“…5,6 We have already reported excellent results for the development of small-diameter vascular grafts made from SF. [7][8][9][10] These novel vascular grafts made from SF (length: 8 mm; internal diameter: 1.5 mm) improved the patency of the graft remarkably, that is, more than 85% patency remained after 1 year of implantation in rat abdominal aorta. 8,9 Although the SF fiber is superior in patency compared with other synthetic materials used in grafts, it is difficult to use the SF alone as an artificial vascular graft because of its poor mechanical stability, such as its low yielding property and weakness against bending.…”

Section: Introductionmentioning

confidence: 90%

Structural characterization of silk-polyurethane composite material for biomaterials using solid-state NMR

Nakazawa

Asano

Nakazawa

et al. 2012

Polym J

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In this paper, we performed solid-state nuclear magnetic resonance (NMR) measurements, including T 1 H and T 1q , of silk fibroin (SF)/polyurethane (PU) composites to examine their possible use as a material for artificial vascular grafts. In the development of new artificial vascular grafts made from SF/PU, it is important to examine the miscibility of the composites and their molecular dynamics, because these properties are intimately involved in the resulting physical properties of the resulting vascular graft. The T 1 H measurements showed that the domain size of the SF/PU ¼ 1:1 composite is smaller than the domain size of the 1:10 and 1:2 composites, indicating that the molecular miscibility between SF and PU are partially in close proximity, particularly in the SF/PU ¼ 1:1 composite. Additionally, we observed that the molecular motion of the soft segment of PU in the SF/PU composites becomes slow, suggesting that the soft segment of PU interacts with SF to some extent. These analyses provided basic structural information for the development of silk-based artificial vascular grafts using PU.

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“…9 In our previous studies, [10][11][12] SF grafts proved to be effective, as VG implanted in rat models. Owing to the success of these in vivo experiments, it has become important to obtain information on the state and mobility of water molecules around and inside of the graft with respect to thrombosis.…”

Section: Introductionmentioning

confidence: 91%

1H MRI study of small-diameter silk vascular grafts in water

Kuroki

Kanekiyo²,

Yazawa

et al. 2012

Polym J

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Small-diameter vascular grafts (VG) made from silk fibroin (SF) fibers by a double-raschel knitting method were prepared by coating their interior and exterior with different materials, such as SF or polyurethane (PU). The 1 H spin density, 1 H spin-spin relaxation time (T 2 ) and diffusion coefficient (D) of the water molecules in the layer of the VG coated by these materials were non-destructively observed in water using 1 H NMR imaging. The inner and outer coating materials significantly affected the amount and mobility of water molecules in the VG. The water content of the SF-coated VG was considerably higher than that of PU-coated VG. The T 2 value of the water molecules in the SF-coated VG layer was smaller than that of the PU-coated VG, which means that the rotational motion of the water molecules in the layer of the SF-coated VG was restricted by the intermolecular interaction between the SF and water molecules. The diffusion coefficient (D) of the water molecules in the SF-coated VG layer was larger than that of the PU-coated VG, indicating that the water molecules were confined to the pores in the graft layer of the PU-coated VG.

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Small-diameter vascular grafts of Bombyx mori silk fibroin prepared by a combination of electrospinning and sponge coating

Cited by 41 publications

References 10 publications

Electrospun scaffolds for tissue engineering of vascular grafts

Electrospun scaffolds for tissue engineering of vascular grafts

Structural characterization of silk-polyurethane composite material for biomaterials using solid-state NMR

1H MRI study of small-diameter silk vascular grafts in water

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