Small-Diameter Vascular Graft Prostheses: Current Status

Bos, Gert W.; Poot, Andreas A.; Beugeling, T.; Aken, W.G. van; Feijén, Jan

doi:10.1076/apab.106.2.100.4384

Cited by 134 publications

(83 citation statements)

References 72 publications

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“…Current synthetic vascular grafts cannot be used to replace narrow arteries with a diameter smaller than 6 mm due to the high risk of thrombosis rapidly after implantation and later intimal hyperplasia [5,30,38]. In such cases, a saphenous vein graft is used instead.…”

Section: Discussionmentioning

confidence: 99%

Electrospinning of Nanocomposite Fibrillar Tubular and Flat Scaffolds with Controlled Fiber Orientation

2011

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Electrospinning was used in innovative electrospinning rigs to obtain tubular and flat fibrous structures with controlled fibre orientation with the aim to be used as scaffolds for biomedical applications, more specifically in the tissue engineering of vascular and orthopaedic grafts.Gelatine and hydroxyapatite (HA)-gelatine solutions of various compositions were tried and electrospinning of continuous fibres was maintained for gelatine and up to 0.30 g/g HAgelatine solutions in 2,2,2-trifluoroethanol (TFE). Small diameter tubular scaffolds were electrospun with axial fibre orientation and flat scaffolds were cut from fibre mats electrospun around a wired drum substrate. The fibrous mats were crosslinked using a glutaraldehyde solution and subjected to image analysis of SEM micrographs, water swelling tests, and mechanical testing. Fibre diameter in the electrospun scaffolds could be varied depending on the feed solution concentration and composition whereas fibre orientation was affected by the processing conditions. After crosslinking, the 0.30 g/g HA-gelatine scaffolds absorbed the minimum amount of water after 48 h soaking and they had the highest Young's modulus, 60 MPa, and highest strength, 3.9 MPa.

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Section: Discussionmentioning

confidence: 99%

Electrospinning of Nanocomposite Fibrillar Tubular and Flat Scaffolds with Controlled Fiber Orientation

2011

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“…Their major limitation is that they cannot be used for arteries of less than 6 mm diameter due to the high risk of thrombosis rapidly after implantation and later intimal hyperplasia [1,2]. For replacing small arteries, e.g.…”

Section: Introductionmentioning

confidence: 99%

Gelatine and Gelatine/Elastin Nanocomposites for Vascular Grafts: Processing and Characterization

et al. 2010

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This study involves the preparation, microstructural, physical, mechanical and biological characterization of novel gelatine and gelatine/elastin gels for their use in the tissue engineering of vascular grafts. Gelatine and gelatin/elastin nanocomposite gels were prepared via a sol-gel process, using soluble gelatine. Gelatine was subsequently crosslinked by leaving the gels in 1% glutaraldehyde. The crosslinking time was optimized by assessing the mass loss of the crosslinked gels in water and examining their mechanical properties in dynamic mechanical tests. AFM (atomic force microscopy) studies revealed elastin nanodomains, homogeneously distributed and embedded in a bed of gelatine nanofibrils in the 30/70 elastin/gelatine gel. It was concluded that the manufactured nanocomposite gels resembled natural arteries in terms of microstructure and stiffness. The biological characterization involved the culture of rat SMCs (smooth muscle cells) on tubular gelatine and gelatine/elastin nanocomposite gels, measurements of the scaffold diameter and the cell density as a function of time.3

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“…Specifically, while some materials have been used with adequate success in replacing portions of the aorta (" Antiplatelet" 1994), once vessel diameters decrease to less than 6 mm, synthetic vascular graft failures increases to greater than 40% (Sayers et al 1998). Frequently, these failures are attributed to thrombosis and poor healing characteristics (Bos et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Fibroblast and Vascular Cell Adhesion to Nano-Structured Poly(lactic-co-glycolic acid) Films

Miller

Vance

Thapa

et al. 2005

Applied Bionics and Biomechanics

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Abstract:The success of small diameter vascular grafts may be attributed to the ability to accurately mimic the nano-structured topography of extra-cellular matrix components of natural vascular tissue. Using this knowledge, the goal of the present study was to develop synthetic biomaterials that promote vascular cell adhesion and growth, while subsequently limiting fibrous tissue formation. For this purpose, poly(lactic-co-glycolic acid) (PLGA) with increased nanometer surface roughness was created by treating the surfaces of conventional PLGA with NaOH. Cell experiments on these surfaces indicated that nano-structured PLGA enhanced vascular smooth muscle cell adhesion and growth, while decreasing endothelial cell and fibroblast adhesion and growth, compared to their conventional counterparts. These favorable results were attributed to the selective adsorption of vitronectin. In combination, results of the present in vitro study provided evidence that nano-structured surface features have the potential to significantly improve the efficacy of small diameter vascular implants.

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Small-Diameter Vascular Graft Prostheses: Current Status

Cited by 134 publications

References 72 publications

Electrospinning of Nanocomposite Fibrillar Tubular and Flat Scaffolds with Controlled Fiber Orientation

Electrospinning of Nanocomposite Fibrillar Tubular and Flat Scaffolds with Controlled Fiber Orientation

Gelatine and Gelatine/Elastin Nanocomposites for Vascular Grafts: Processing and Characterization

Comparison of Fibroblast and Vascular Cell Adhesion to Nano-Structured Poly(lactic-co-glycolic acid) Films

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