Small-diameter polyurethane vascular graft with high strength and excellent compliance

Zhang, Baocheng; Xu, Yuan; Ma, Sitian; Wang, Linfeng; Liu, Changjun; Xu, Weilin; Shi, Jing; Qiao, Weihua; Yang, Hongjun

doi:10.1016/j.jmbbm.2021.104614

Cited by 26 publications

(16 citation statements)

References 35 publications

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“…To match the nonlinear behavior of arteries and prevent graft leakage, Mi et al 194 fabricated a triple-layered graft with braided silk fibroin as the inner layer to promote rapid endothelialization, prevent IH, and mimic the collagen behavior at high strain. PAM hydrogel was used as the middle layer to prevent leakage, and the outer layer was made of TPU to mimic the high elasticity of elastin.…”

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

“…The major disadvantage of electrospinning is that, in most cases, the final electrospun mat does not possess sufficient mechanical properties to resist the hemodynamic forces experienced after implantation of the graft and leakage of liquid under pressure. 194 …”

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

“… Fabrication and characterization of a triple-layered hybrid graft 194 (1) Schematic illustration of the fabrication procedure (2) (A) Overview of SDVG cross section, (B) enlarged region showing the three layers, (C) cross section of TPU layer, (D) cross section of braided silk and PAM layers, (E) morphology of the inner surface, and (F) morphology of the outer surface. (3) (A) Fluorescence images of HUVECs cultured on braided silk, TPU nanofibers, and the PAM hydrogel from live/dead assays.…”

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

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Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

2022

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Small-diameter artificial vascular grafts (SDAVG) are used to bypass blood flow in arterial occlusive diseases such as coronary heart or peripheral arterial disease. However, SDAVGs are plagued by restenosis after a short while due to thrombosis and the thickening of the neointimal wall known as intimal hyperplasia (IH). The specific causes of IH have not yet been deduced; however, thrombosis formation due to bioincompatibility as well as a mismatch between the biomechanical properties of the SDAVG and the native artery has been attributed to its initiation. The main challenges that have been faced in fabricating SDAVGs are facilitating rapid re-endothelialization of the luminal surface of the SDAVG and replicating the complex viscoelastic behavior of the arteries. Recent strategies to combat IH formation have been mostly based on imitating the natural structure and function of the native artery (biomimicry). Thus, most recently, developed grafts contain a multilayered structure with a designated function for each layer. This paper reviews the current polymeric, biomimetic SDAVGs in preventing the formation of IH. The materials used in fabrication, challenges, and strategies employed to tackle IH are summarized and discussed, and we focus on the multilayered structure of current SDAVGs. Additionally, the future aspects in this area are pointed out for researchers to consider in their endeavor.

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Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

See 2 more Smart Citations

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

2022

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“…In addition, blood penetration has always been an important factor affecting the success of vascular transplantation. Polyurethane (PU) is considered an excellent coating material because of its excellent expansibility, biocompatibility, and processability [ 25 , 26 ]. Therefore, in order to overcome the problem of blood penetration, we introduced polyurethane between the PET fabric and gelatin coating [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

et al. 2022

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Medical apparatus and instruments, such as vascular grafts, are first exposed to blood when they are implanted. Therefore, blood compatibility is considered to be the critical issue when constructing a vascular graft. In this regard, the coating method is verified to be an effective and simple approach to improve the blood compatibility as well as prevent the grafts from blood leakage. In this study, polyester fabric is chosen as the substrate to provide excellent mechanical properties while a coating layer of polyurethane is introduced to prevent the blood leakage. Furthermore, gelatin is coated on the substrate to mimic the native extracellular matrix together with the improvement of biocompatibility. XPS and FTIR analysis are performed for elemental and group analysis to determine the successful coating of polyurethane and gelatin on the polyester fabrics. In terms of blood compatibility, hemolysis and platelet adhesion are measured to investigate the anticoagulation performance. In vitro cell experiments also indicate that endothelial cells show good proliferation and morphology on the polyester fabric modified with such coating layers. Taken together, such polyester fabric coated with polyurethane and gelatin layers would have a promising potential in constructing vascular grafts with expected blood compatibility and biocompatibility without destroying the basic mechanical requirements for vascular applications.

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A review on polyurethane based multifunctional materials synthesis for advancement in textile coating applications

Ghonia,

Savani,

Prajapati

et al. 2024

J Polym Res

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Small-diameter polyurethane vascular graft with high strength and excellent compliance

Cited by 26 publications

References 35 publications

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

A review on polyurethane based multifunctional materials synthesis for advancement in textile coating applications

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