Small Choroidal Melanoma: Correlation between Clinical Characteristics and Metastatic Potential

Abstract

<b><i>Importance:</i></b> Diagnosis of small choroidal melanoma is based upon clinical features and presence of factors predictive of local malignant growth. Prognostic biopsy quantifies risk of metastasis. <b><i>Objective:</i></b> The aim of this study is to explore relationship between clinical characteristics and metastatic potential of a small choroidal melanoma. <b><i>Design:</i></b> Retrospective review of 53 patients with small choroidal melanoma treated in a tertiary oncology clinic. Patients were derived from 3 cohorts, with pathologic confirmation, with growth confirmation, and those treated only on clinical basis. Based upon prognostic biopsy outcomes, each case was classified into low or high metastatic potential groups. Distribution of clinical characteristics such as age, laterality, symptoms, tumor dimensions, tumor distance from optic nerve and fovea, presence of surface orange pigment, drusen, retinal pigment epithelial atrophy, and subretinal fluid was analyzed between metastatic groups. <b><i>Main Outcome Measures:</i></b> Distribution of clinical characteristics between low or high metastatic potential groups was analyzed. <b><i>Results:</i></b> A total of 53 patients [mean age, 61 years (range, 27–81 years); 32 (60%) men and 21 (40%) women] were classified into pathology confirmed group (<i>n</i> = 13), growth confirmed group (<i>n</i> = 26), and with clinical group (<i>n</i> = 14). Prognostic biopsy in the growth, pathology, and clinical groups revealed low metastatic potential in 23, 10, and 11 patients, respectively, and high metastatic potential in 3 patients in each group. Distribution of clinical characteristics between low or high metastatic potential groups was not statistically significantly different. <b><i>Conclusion:</i></b> Clinical characteristics do not identify metastatic potential of a small choroidal melanoma.