Small changes in six-minute walk distance are important in diffuse parenchymal lung disease

Holland, Anne E; Hill, Catherine J.; Conron, Matthew; Munro, Prue; McDonald, Christine F

doi:10.1016/j.rmed.2009.04.024

Cited by 113 publications

(116 citation statements)

References 34 publications

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“…Based on a large cohort of 822 IPF patients the MCID for the 6MWD was calculated to be 24-45 m, depending on the statistical method employed [28]. This is in line with the previous studies of HOLLAND et al [29] who assumed an improvement of 6MWD in the range 29-34 m to be clinically relevant in people with parenchymal lung disease, and SWIGRIS et al [30] who calculated the MCID for 6MWD to be 28 m. Thus, the improvement in 6MWD of 46 m is among the highest MCID discussed and reflects a meaningful increase in exercise capacity in our patients. In contrast to the previously cited study populations, we have to highlight that 299 of our patients (74%) were listed for lung transplantation.…”

Section: Figuresupporting

confidence: 67%

Effects of inpatient pulmonary rehabilitation in patients with interstitial lung disease

Huppmann

Sczepanski²,

Boensch³

et al. 2012

Eur Respir J

159

110

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Pulmonary rehabilitation is recommended for patients with chronic lung diseases including idiopathic pulmonary fibrosis according to international guidelines. However, data for patients with interstitial lung disease (ILD) are limited. We examined the effect of an inpatient pulmonary rehabilitation on functional status and quality of life in ILD patients.We evaluated 402 consecutive ILD patients who were admitted to a specialised pulmonary rehabilitation centre (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010). All patients performed a standardised pulmonary rehabilitation programme including pulmonary function tests, blood-gas analysis, 6-min walk test (6MWT), dyspnoea rating and health-related quality of life questionnaire (the 36-item short-form health survey; SF-36) on admission and discharge.Mean duration of pulmonary rehabilitation was 30¡1 days. 6MWT distance improved by 46¡3 m (308¡6 m versus 354¡6 m; p,0.001). Dyspnoea rating did not change. Lung function testing showed marginal improvement of vital capacity (+1¡0%; p50.002). The SF-36 questionnaire demonstrated an increase in all eight sub-scores as well as in the physical and mental health summary scores (physical 6¡1 points, p,0.001; mental health 10¡1 points, p,0.001). Moreover, patients with signs of pulmonary hypertension also benefited from pulmonary rehabilitation.In a large cohort of patients with ILD, pulmonary rehabilitation had a positive impact on functional status and quality of life. Considering the limited treatment options in this patient population pulmonary rehabilitation appears to be a valuable adjunct therapy. @ERSpublications Pulmonary rehabilitation improved functional status and QoL in a large cohort of ILD patients and appears to be a valuable adjunct therapy

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Section: Figuresupporting

confidence: 67%

Effects of inpatient pulmonary rehabilitation in patients with interstitial lung disease

Huppmann

Sczepanski²,

Boensch³

et al. 2012

Eur Respir J

159

110

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“…172,174 More often, rather than reporting point estimates, studies reported a range of values for important differences, based on all methods used. 211,314,377,378 Other studies used anchor-based values rather than distributionbased values to infer the level of an important difference. 175,379,380 One study used the distribution method estimate rather than the anchor method estimate because the distribution value was higher and therefore a more conservative estimate.…”

Section: Combining Results Derived From Multiple Methodsmentioning

confidence: 99%

Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review

Cook

Hislop

Adewuyi

et al. 2014

Health Technology Assessment

111

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“…Chest expansion improved significantly at both IC level by 29% (1.3 cm; p = .002) and XP level by 29% (1.3 cm; p = .003). The 6MWD increased significantly by 6% (31.6 m; p = .028) and the change reached the MCID for 6MWD, which is 30-33 m in patients with diffuse parenchymal lung disease (Holland, Hill, Conron, Munro, & McDonald, 2009). Lung function showed no significant improvements after the rehabilitation programme.…”

Section: Resultsmentioning

confidence: 90%

An effect of the outpatient rehabilitation programme in patients with chronic respiratory diseases

Zatloukal¹,

Neumannová²,

Olšáková³

et al. 2013

Acta Gymnica

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BACKGROUND: Pulmonary rehabilitation is a common type of complex treatment especially in patients with chronic obstructive pulmonary disease (COPD). By contrast, only few rehabilitation centres in the Czech Republic provide pulmonary rehabilitation programme to non-COPD patients. OBJECTIVE: To find out if the rehabilitation programme has a similar effect in patient with obstructive and restrictive ventilatory disorder. METHODS: Twenty-eight patients with either COPD or pulmonary sarcoidosis (PS) have been enrolled for the 6-week rehabilitation programme. Lung functions, maximal inspiratory (MIP) and expiratory (MEP) mouth pressures, chest expansion at the level of the 4th intercostal space (IC) and at the level of the xiphoid process (XP), sixminute walk test, health-related quality of life using the St. George's Questionnaire (SGRQ) and fatigue occurrence using the Multidimensional Assessment of Fatigue scale (MAF) were tested at the baseline and after 6 weeks. The rehabilitation programme consisted of exercise training, ventilatory muscle training, respiratory physiotherapy and soft-tissue techniques. RESULTS: Patients with COPD improved significantly (p < .05) in MIP by 17% (10.5 cm H 2 O), MEP by 18% (16.8 cm H 2 O), IC by 65% (1.7 cm), XP by 90% (1.9 cm), six-minute walk distance (6MWD) by 15% (64.1 m) and SGRQ by -28% (-12.3 points). Patients with PS improved significantly (p < .05) in MIP by 25% (20.1 cm H 2 O), IC by 29% (1.3 cm), XP by 29% (1.3 cm) and 6MWD by 6% (31.6 m). The change in lung functions and MAF in both groups; MEP and SGRQ in PS group were insignificant after the 6-week rehabilitation programme. CONCLUSIONS: The 6-week rehabilitation programme produces similar responses in functional health status of patients with either obstructive or restrictive ventilatory disorder. However, patients with restrictive ventilatory disorder in particular should be encouraged to continue in the programme to enhance the health-related quality of life, which might not be sufficiently affected after 6 weeks.

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Small changes in six-minute walk distance are important in diffuse parenchymal lung disease

Abstract: Small differences in six-minute walk distance, in the range 29-34 m, may be clinically significant for people with diffuse parenchymal lung disease.

Cited by 113 publications

References 34 publications

Effects of inpatient pulmonary rehabilitation in patients with interstitial lung disease

Effects of inpatient pulmonary rehabilitation in patients with interstitial lung disease

Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review

An effect of the outpatient rehabilitation programme in patients with chronic respiratory diseases

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