Small cell (OAT cell) carcinoma of minor salivary gland origin

Koss, Leopold G.; Spiro, Ronald H.; Hajdu, Steven I.

doi:10.1002/1097-0142(197209)30:3<737::aid-cncr2820300322>3.0.co;2-m

Cited by 179 publications

(79 citation statements)

References 10 publications

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“…Oropharyngeal metastasis is very rare, and metastasis to the palatine tonsil has been described in only one case [27]. A perioral or intraoral localisation of the MCC is very infrequent: [13,20] to date, 10 cases of MCC of the lip [35] and 14 cases of intraoral MCCs have been described [3,16,20]. During the past decade, we treated and followed up an elderly woman with MCC of the upper lip.…”

Section: Introductionmentioning

confidence: 99%

A second field metachronous Merkel cell carcinoma of the lip and the palatine tonsil confirmed by microarray-based comparative genomic hybridisation

Nagy¹,

Feher²,

Sonkodi³

et al. 2005

Virchows Arch

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Merkel cell carcinoma was diagnosed in a 79-year-old Caucasian woman. The tumour was localised to the upper lip and was in stage T2. After successful cryosurgery and a 7-year tumour-free period, a new tumour developed in her palatine tonsil. Histologically and immunohistochemically, this resembled the tumour in the lip. The regional lymph nodes were devoid of metastasis. The paraffin-embedded material of the two tumours and the unaffected lymphatic tissue were analysed with DNA microarrays for comparative genomic hybridisation to assess the genetic relationship of the tumours. In both tumours, regions on 2p and 10p were commonly over-represented, while 41 regions on chromosomes 1-4, 6, 8-9, 11 and 14-22 were commonly under-represented. Chromosomes 1, 3, 4, 16-18 and X were most frequently involved in the DNA losses. In gene copy numbers in the two tumours, 31 chromosome locations were found to be differently affected. The partly similar and partly different molecular patterns indicated a genetic relationship between the tumours and excluded the possibility that the tonsillar tumour was a metastasis. The findings suggest that a genetically altered field was the reason for the development of the tonsillar cancer; thus, it can be regarded pathogenetically as a second field tumour.

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Section: Introductionmentioning

confidence: 99%

A second field metachronous Merkel cell carcinoma of the lip and the palatine tonsil confirmed by microarray-based comparative genomic hybridisation

Nagy¹,

Feher²,

Sonkodi³

et al. 2005

Virchows Arch

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“…In our case, this neoplasm presented in young female child of 11 years of age. These tumors primarily arise in major salivary glands 3 , commonly the parotid, as well as larynx, but rarely occur in the sino-nasal region and hard palate.…”

Section: Discussionmentioning

confidence: 99%

“…Small cell undifferentiated (neuroendocrine) carcinoma in the head and neck region arises primarily from salivary glands, mainly parotid as well as in larynx, but rarely/uncommonly in the sino-nasal region 3 . The common neoplasms in the sino-nasal tract are squamous cell carcinoma, followed by Adenocarcinoma which is seen in older age, associated with history of smoking and chronic sinusitis.…”

Section: Introductionmentioning

confidence: 99%

Small Cell Undifferentiated (Neuroendocrine) Tumor – Maxillary Sinus.

Bharath¹,

Rampure²

2013

jemds

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BACKGROUND:Small cell undifferentiated (neuroendocrine) carcinomas in head and neck region is extremely uncommon neoplasm. These belong to the group of other blue cell tumors. CASE REPORT: An 11 year's girl presented with swelling in right cheek since 3 months, watering of right eyesince2 months & bleeding since1 month. Examination revealed soft to firm mass in inferior meatus and was bleeding on touch. CT scan showed heterogeneous density in maxillary antrum. Biopsy was done. Histopathologically, diagnosis of Small cell carcinomaundifferentiated (neuroendocrine) type of maxillary sinus was made. CONCLUSION: These neoplasms of the nasal and paranasal sinuses are locally aggressive and have propensity for multiple local recurrences, and thus, early diagnosis and local control may be important for improved prognosis.

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“…They appeared to be poorly differentiated, small cell epidermoid carcinomas, rather than oat cell carcinomas. This assumption is based on the following findings: (1) The biologic behavior of some of these small cell carcinomas arising from salivary glands' appears to be considerably less aggressive than that of classic or bona fide oat cell carcino¬ ma of either bronchial or head and neck origin. Our first patient is alive and free of disease seven years after diagnosis, and the second is alive with cervical and pulmonary metastasis four years after initial treatment.…”

Section: Commentmentioning

confidence: 99%

Small Cell Epidermoid Carcinoma of Salivary Glands: 'Pseudo'--Oat Cell Carcinoma

Leipzig¹,

Gonzales-Vitale²

1982

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\Two patients had small cell carcinomas of the salivary glands, with pathological features indicating squamous differentiation, heretofore not described. One is free of disease at seven years, and the second is alive, with regional metastases at four years. Sections from one tumor were studied by electron microscopy and revealed tonofilaments and desmosomes. Most cases of small cell carcinomas of the salivary glands have been considered akin to bronchogenic oat cell carcinoma. Their less aggressive behavior, however, suggests that at least some of these tumors were not true oat cell carcinomas.Our findings, and those of others, indicate that small cell carcinomas of the salivary glands (or head and neck) represent a heterogeneous group. Electron microscopy should be used to determine the exact nature of these neoplasms. If an oat cell nature is ruled out, local and regional treatment should be aggressive, since small cell carcinomas other than oat cell appear not to have a dismal prognosis. (Arch Otolaryngol 1982;108:511-514) oss et al,1 in 1972, reported 14 cases of small cell carcinoma of the minor salivary glands, which they described as "histologically akin to oat-cell carcinoma of the bronchus," even though one case showed a spindle and giant cell component and a second exhibited foci of keratinization. The biologic behavior of some of those tumors1 was much less aggressive than that of oat cell carcinoma of bronchial origin. Later, Wirman and Battifora2 described the ultrastruc¬ tural features of another small cell carcinoma of the salivary gland-sim¬ ilar to those described by Koss et al-from their observations on light microscopy. These observations did not support an identification as an oat cell type. Instead, they established that this tumor was a distinct neo¬ plasm originating in salivary duct epi¬ thelium. A review of the literature showed that oat cell carcinomas of the head and neck, documented by the ultrastructural demonstration of neurosecretory granules in the tumor cells, have invariably had a fatal out¬ come.3"5 In this article, we describe another distinct parotid small cell neoplasm. The clinical, light microscopic, and ultrastructural features of two cases of small cell carcinoma demonstrated squamous or epidermoid differentia¬ tion. REPORT OF CASES Case 1.-A 47-year-old man was admit¬ ted to the Hospitals of the University of Texas Medical Branch at Galvestonbecause of an enlargement of the left par¬ otid gland and pain in the left jaw of about six months' duration. The parotid gland had enlarged gradually over this period of time, but the pain had been the same. The patient underwent a total parotidectomy with sacrifice of the left facial nerve. A tumor of the deep lobe of the gland was found (see "Pathological Findings").Following surgery, the patient received radiation treatment, 6,000 rad to the surgi¬ cal area and the left cervical lymph nodes. Two years later, a peripheral nodule of the lower lobe of the left lung was resected, and pathological examination revealed a metasta...

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Small cell (OAT cell) carcinoma of minor salivary gland origin

Cited by 179 publications

References 10 publications

A second field metachronous Merkel cell carcinoma of the lip and the palatine tonsil confirmed by microarray-based comparative genomic hybridisation

A second field metachronous Merkel cell carcinoma of the lip and the palatine tonsil confirmed by microarray-based comparative genomic hybridisation

Small Cell Undifferentiated (Neuroendocrine) Tumor – Maxillary Sinus.

Small Cell Epidermoid Carcinoma of Salivary Glands: 'Pseudo'--Oat Cell Carcinoma

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