Small Cell Neuroendocrine Carcinoma of the Oropharynx Harbouring Oncogenic HPV-Infection

Bates, Timothy; McQueen, Andrew; Iqbal, Muhammad Shahid; Kelly, Charles; Robinson, Max

doi:10.1007/s12105-013-0471-y

Cited by 29 publications

(37 citation statements)

References 30 publications

(57 reference statements)

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“…Thus, an HPV-positive form of small cell carcinoma would not have been readily appreciated at the writing of the 2005 edition of the Blue Book. Like small cell carcinomas of the lung, these HPV-positive small cell carcinomas of the oropharynx are associated with cigarette smoking, high grade cellular features, expression of neuroendocrine markers, and an aggressive clinical behavior including widespread dissemination and poor survival [24][25][26]. This aggressive clinical behavior is in sharp contrast to non-small cell carcinomas of the oropharynx where the presence of HPV is associated with highly favorable survival rates.…”

Section: Small Cell Carcinomamentioning

confidence: 99%

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Westra

Lewis

2017

Head and Neck Pathol

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Section: Small Cell Carcinomamentioning

confidence: 99%

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Westra

Lewis

2017

Head and Neck Pathol

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“…Subtypes 16, 18 and 33 have been identified at this site 13 14. HPV has also been associated with small cell neuroendocrine carcinoma of the cervix with subtypes 18 and 16 reported in up to 40% of cases 15.…”

Section: Discussionmentioning

confidence: 92%

Small cell neuroendocrine carcinoma of tracheostomy site in a patient with a history of juvenile laryngeal papillomatosis

Wilmot

Nixon

Nixon³

2016

BMJ Case Reports

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Juvenile laryngeal papillomatosis is the commonest cause of benign epithelial tumours of the larynx. Following diagnostic biopsy, surgical debulking is the mainstay of therapy. The condition is often recurrent with further papillomas forming after debridement, requiring serial procedures and occasionally demanding tracheostomy. Rarely, the disease can undergo malignant transformation; most commonly to squamous cell carcinoma. We describe the first reported case of small cell neuroendocrine carcinoma occurring in the previous tracheostomy site of a 29-year-old male with a history of juvenile laryngeal papillomatosis. The patient, with a background of multiple treatments for juvenile papillomas, presented with voice change, breathing difficultly and erythema at the site of previous tracheostomy. Induction chemotherapy followed by chemoradiation was used to treat the lesion with a good response to initial therapy.

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“…HPV‐related small cell carcinoma of the oropharynx is a newly recognized variant with few cases reported in the literature . This study presents one of the first comprehensive cytologic characterizations of this entity and includes 6 patients.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to SqCC variants, HPV‐related small cell carcinomas follow an aggressive clinical course and are almost uniformly fatal. To date, fewer than 2 dozen cases of HPV‐related small cell carcinoma of the oropharynx have been reported in the literature . Despite the growing use of fine‐needle aspiration (FNA) cytology for the evaluation of neck masses and masses at other sites and the adequate performance of these specimens for HPV testing, there are no reports in the literature describing the cytomorphologic features of this entity .…”

Section: Introductionmentioning

confidence: 99%

Cytopathologic characteristics of HPV‐related small cell carcinoma of the oropharynx

Allison

Rooper

Mustafa

et al. 2018

Cancer Cytopathology

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Background Human papillomavirus (HPV)–related squamous cell carcinoma (SqCC) of the oropharynx is an epidemiologically and clinically distinct form of SqCC that is associated with an improved prognosis. However, HPV‐related small cell carcinoma of the oropharynx is a rare and newly described variant that is associated with aggressive clinical behavior and poor outcomes. To date, fewer than 2 dozen reports of this entity exist in the literature, and there is no discussion of cytopathologic features. This article reports 6 cases and discusses the salient cytomorphologic findings, ancillary studies, and challenges when this entity is encountered. Methods Anatomic pathology archives were searched to identify patients with a diagnosis of HPV‐related small cell carcinoma of the oropharynx. Medical records were reviewed to document the following: age, sex, smoking status, other relevant clinical history, primary location, treatment, and clinical outcome. Both p16 and high‐risk HPV in situ hybridization (ISH) studies were positive in at least 1 specimen from each patient. The pathologic diagnoses, cytomorphologic characteristics, immunocytochemical stains, and HPV ISH studies were reviewed and recorded for all available cases. Results Six patients with 11 cytopathology specimens of HPV‐related small cell carcinoma of the oropharynx were identified. The mean age was 61.3 years, and all patients died with widely metastatic disease (mean, 23 months; range, 12‐48 months). Mixed small cell carcinoma and SqCC components were present in half of the cases. Conclusions The identification of a small cell component can be reliably performed with cytology preparations and is crucial because this (and not the HPV status) determines the prognosis.

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Small Cell Neuroendocrine Carcinoma of the Oropharynx Harbouring Oncogenic HPV-Infection

Cited by 29 publications

References 30 publications

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Small cell neuroendocrine carcinoma of tracheostomy site in a patient with a history of juvenile laryngeal papillomatosis

Cytopathologic characteristics of HPV‐related small cell carcinoma of the oropharynx

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