Small cell neuroendocrine carcinoma of vagina: Report of a unique case with literature review

Pongsuvareeyakul, Tip; Garcia-Moliner, Maria; Lokich, Elizabeth; Dizon, Don S.; Singh, Kamaljeet

doi:10.1016/j.ctarc.2022.100645

Cited by 1 publication

(2 citation statements)

References 26 publications

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“…In about 2% of malignancies, small cell carcinoma is diagnosed in the female genital tract. Clinical reported features may vary from asymptomatic presentation to dyspareunia, burning micturition, post-menopausal bleeding, and vaginal mass [ 3 , 7 , 8 ]. The cervix in the female genital tract is the most commonly involved and then, respectively, the ovary, endometrium, vagina, and finally, the vulva.…”

Section: Discussionmentioning

confidence: 99%

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Small Cell Neuroendocrine Carcinoma of the Vagina: A Rare Presentation

Asghar¹,

Usman²,

Sheikh³

et al. 2023

Cureus

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Primary small cell neuroendocrine carcinoma of the vagina is a very rare disease. We present a case study of a 52-year-old female who presented to the hospital with complaints of urinary dribbling, burning micturition, pain, and per vaginal bleeding for three to four months. A firm globular mass of approximately 5-6 cm was felt in the anterior vaginal wall per speculum examination. Diagnosis of small cell neuroendocrine carcinoma was made with tissue biopsy and immunohistochemistry. Diagnostic imaging (MRI, positron emission tomography (PET)-CT) plays a vital role in reaching the diagnosis and understanding the treatment response. The patient received six cycles of chemotherapy with cisplatin and etoposide and radiotherapy, achieving a complete response, with complete regression of the lesion. The patient had no sign of tumor recurrence and locoregional or distant metastases after six months of follow-up. Nowadays, there is no need for surgery in the treatment of vaginal small cell neuroendocrine carcinoma, rather radiotherapy and chemotherapy are the treatment of choice. We report a case of neuroendocrine cancer of the vagina treated at our institution.

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Section: Discussionmentioning

confidence: 99%

“…Only less than 2% of all gynecologic cancer comprises small cell neuroendocrine carcinoma of the vagina [1][2][3]. It is an extremely malignant aggressive tumor with a poor prognosis [4][5][6].…”

Section: Introductionmentioning

confidence: 99%