Small Cell Neuroendocrine Carcinoma: A Rare Nasopharyngeal Malignancy with Aggressive Clinical Course

Bhardwaj, Nishu; Kakkar, Aanchal; Irugu, David Victor Kumar

doi:10.1007/s12070-018-1344-1

Cited by 10 publications

(12 citation statements)

References 21 publications

(27 reference statements)

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“…However, the patient eventually died of liver failure caused by further multiple liver metastases. The OS of the patient is about 18 months, which is at an intermediate level among the current literature results [3][4][5][6][7][8][9][10] . According to the literature retrieved so far, nasopharyngeal neuroendocrine carcinoma has the risk of central nervous system metastasis, and it is necessary to carry out prophylactic cranial irradiation [11] .…”

Section: Discussionmentioning

confidence: 89%

A case report of nasopharyngeal neuroendocrine carcinoma

Zhang

Wang

et al. 2022

Preprint

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Background: The purpose of this article is to report the treatment outcome of a patient with nasopharyngeal neuroendocrine carcinoma.Method: The patient received concurrent chemoradiotherapy(CRT) for the primary lesion and microwave ablation for isolated hepatic metastasis later.Results: Complete remission (CR) was achieved after the completion of concurrent CRT. However, prophylactic cranial irradiation(PCI) was not performed. Isolated hepatic metastasis was diagnosed 3 months after the completion of CRT. Then microwave ablation for isolated hepatic metastasis was performed cc. Finally, unlike the most common death caused by brain metastasis in literature retrieval, the patient died of hepatic function failure caused by multiple hepatic metastasis. The overall survival(OS) of the patient is about 18 months.Conclusion: Standardized concurrent CRT also has a good therapeutic effect on nasopharyngeal neuroendocrine carcinoma.The administration of prophylactic cranial irradiation may not be necessary for nasopharyngeal neuroendocrine carcinoma,which remains to be conformed.

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Section: Discussionmentioning

confidence: 89%

A case report of nasopharyngeal neuroendocrine carcinoma

Zhang

Wang

et al. 2022

Preprint

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“… 2 Nevertheless, the prognosis of nasopharyngeal small cell carcinoma (SmCC), which is a relatively rare type of nasopharyngeal cancer, remains poor. 3 A population-based analysis of the National Cancer Database revealed that only .3% of all head and neck cancer patients were diagnosed as having SmCC, among which 10% were nasopharyngeal in origin. 4 Moreover, nasopharyngeal SmCC has been reported to have the worst prognosis of all SmCCs of the head and neck.…”

Section: Introductionmentioning

confidence: 99%

“…Current strategies for the therapeutic treatment of nasopharyngeal SmCC comprise chemotherapy and/or radiotherapy; surgery can also serve as a therapeutic modality for early stage nasopharyngeal SmCC. 20 - 24 Unfortunately, there are few available studies in this regard. Various therapies, including surgery, radiotherapy, chemotherapy, immune therapy, and combined therapies, 5 , 21 , 25 , 26 have been studied for SmCCs of the head and neck.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Prognosis of Small Cell Carcinoma in the Nasopharynx: A Population-Based Study

et al. 2022

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Background Nasopharyngeal small cell carcinoma (SmCC) is a rare histological type of nasopharyngeal cancer, and its prognosis remains poor. This study aimed to determine the clinical characteristics and survival prognostic factors of nasopharyngeal SmCC. Methods Detailed clinicopathologic and therapeutic characteristics of a patient diagnosed with nasopharyngeal SmCC were determined. Nasopharyngeal SmCC cases reported previously were reviewed and summarized. Furthermore, a retrospective analysis was performed on data from the Surveillance, Epidemiology, and End Results (SEER) Program database. Kaplan–Meier analysis was conducted to compare survival within groups. Univariate and multivariate analyses were performed to investigate prognostic factors. Results A nasopharyngeal SmCC patient treated with chemoradiotherapy who achieved 46 months long-term survival was reported. In reviewing 16 reported cases with epidemiologic and therapeutic details, we found most of nasopharyngeal SmCC patients were diagnosed with advanced grades and received chemoradiotherapy. In total, 13,993 cases of nasopharyngeal cancer were extracted from the SEER database, from which 57 nasopharyngeal SmCC cases were eventually screened out. The mean age of the patients was 55.70 years, and 64.9% of these cases were either grade III or IV; the median overall survival (OS) was 18 months. Statistically significant differences were observed in the OS values of groups categorized by age (P = .025) or radiotherapy (P = .037). Age (<70 years) and radiotherapy were identified as independent survival and prognostic factors. Conclusion Patients with nasopharyngeal SmCC are usually diagnosed with advanced grades and have poor prognoses; nevertheless, they can benefit from radiotherapy with prolonged overall survival.

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“…They usually appear in the sixth or seventh decade of life and carry a poor prognosis 4,5 . Distinction from other conventional nasopharyngeal malignancies can represent a diagnostic challenge as a result of various morphological characteristics that can mimic other small round blue cell tumours, such as neuroblastomas, lymphomas, primitive neuroectodermal tumours, Ewing sarcoma, desmoplastic round cell tumours, NUT midline carcinomas, adenoid cystic carcinomas and basaloid carcinomas 6 . NECs of the nasopharynx can be divided into large cell neuroendocrine carcinoma (LNEC) and small cell neuroendocrine carcinoma (SNEC) 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal neuroendocrine neoplasms: Systematic review of the literature and case presentation

Jain

Dorth

Sylvia

et al. 2021

J Neuroendocrinology

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Most of neuroendocrine neoplasms (NENs) are located in the gastrointestinal tract and lung, and they are rarely found on the upper aero‐digestive tract, which limit the current literature about nasopharyngeal NENs. This systemic review will summarize the clinical, pathological features and optimal diagnosis and management of different types of nasopharyngeal NENs (NP NENs). In‐addition, we herein report an EBV negative TP53‐mutated/ Rb‐wild type nasopharyngeal neuroendocrine carcinoma (NEC) in a young man in which touch preparation cytology studies were integral to establishing a definitive diagnosis. To our knowledge, only very few cases of primary neuroendocrine carcinoma of the nasopharynx have been reported in the literature and the reports of these cases have not included detailed description of different types and how to optimally diagnose and manage them. In this abstract, we also highlighted the evidence about the safety of using growth factors in patients with sickle cell anemia who are receiving cytotoxic chemotherapy.

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Small Cell Neuroendocrine Carcinoma: A Rare Nasopharyngeal Malignancy with Aggressive Clinical Course

Cited by 10 publications

References 21 publications

A case report of nasopharyngeal neuroendocrine carcinoma

A case report of nasopharyngeal neuroendocrine carcinoma

Clinical Characteristics and Prognosis of Small Cell Carcinoma in the Nasopharynx: A Population-Based Study

Nasopharyngeal neuroendocrine neoplasms: Systematic review of the literature and case presentation

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