Small cell lung cancer: emerging subtypes, signaling pathways, and therapeutic vulnerabilities
Jing Zhang,
Xiaoping Zeng,
Qiji Guo
et al.
Abstract:Small cell lung cancer (SCLC) is a recalcitrant cancer characterized by early metastasis, rapid tumor growth and poor prognosis. In recent decades, the epidemiology, initiation and mutation characteristics of SCLC, as well as abnormal signaling pathways contributing to its progression, have been widely studied. Despite extensive investigation, fewer drugs have been approved for SCLC. Recent advancements in multi-omics studies have revealed diverse classifications of SCLC that are featured by distinct character… Show more
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