Small cell carcinoma of the urinary tract: a case report

Abstract

Neuroendocrine small cell carcinoma of the urinary tract is rarely encountered and very few cases have been reported in the literature. Herein we describe a case of small cell malignancy located contemporarily in the ureter and the bladder.

Small Cell Carcinoma of the Renal Pelvis and Ureter: Clinicopathologic and Immunohistochemical Features

“…In addition to the usual markers for neuroendocrine differentiation, we found CD56 to be a useful adjunct in classifying these tumors, which to our knowledge have been previously described in only one recent case from among SCC tumors of the renal pelvis/ureter. 22 Thyroid transcription factor 1 reactivity within SCC was noted in several of our cases (Table 2); however, it varied widely in amount of expression, which is similar to findings noted in SCC of the bladder. 25 Thyroid transcription factor 1 reactivity was consistently negative in the non-small cell component of mixed tumors and the tumors reclassified as non-SCC in our study and is therefore helpful along with the other stains in classification of the histologic subtype.…”

“…We identified a total of 21 cases of previously published SCC of the renal pelvis and/or ureter spanning a period of 23 years. 5,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The clinical and pathologic features of these cases are presented in Table 3, and the comparison discussed below reveals some interesting differences between these and the cases in our series.…”

Urography and CT Features of Primary Small Cell Carcinoma of the Ureter: A Case Report

“…Because of high mitotic activity ( 3 , 8 - 10 ) and the high tumoral mass ( 11 ), SCC of the ureter usually obstructs the ureter completely. The IVU or the MPR CT shows the end of the contrast agent is amputated completely, and the ureter above the obstruction and renal pelvis exhibits severe dilatation.…”

“…SCC of the genitourinary tract has been reported previously in the urinary bladder. Primary small cell carcinoma (PSCC) of the ureter is a rare entity; only several cases have been reported worldwide ( 3 ). The cause of SCC of the ureter may be related to smoking, but it remains unclear ( 4 ).…”

“…The cause of SCC of the ureter may be related to smoking, but it remains unclear ( 4 ). Previous reports have discussed the clinical characteristics and therapeutic methods for SCC ( 3 - 5 ). To date, no report has discussed urography and computed tomography (CT) findings of PSCC of the ureter in detail; thus, we report the urography and CT findings of this PSCC of the ureter.…”