Small cell carcinoma of the lung in a treated case of Myoepithelial carcinoma of the tongue – Report of a rare case with illustrated review of the literature

Venkatesulu, BhanuPrasad; Mallick, Supriya; George, Archana; Bhasker, Suman

doi:10.1016/j.jnci.2015.06.002

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…7 At the time of publication, all current case reports of primary tongue MCC describe tumors that appear to have originated in the base of tongue. 8,9…”

Section: Discussionmentioning

confidence: 99%

“…7 At the time of publication, all current case reports of primary tongue MCC describe tumors that appear to have originated in the base of tongue. 8,9 Myoepithelial cells constitute an important component of glandular acini and ducts. They are normally located between the luminal epithelial cells and the basement membrane and have contractile function.…”

Section: History and Clinical Characteristics Of MCCmentioning

confidence: 99%

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Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature

Nicholas

Hanson

Meiklejohn

2019

Clin Med Insights Oncol

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Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue. Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Physical examination demonstrated a 2.5 cm ulcerative lesion of the anterior right oral tongue. An initial biopsy was consistent with moderately to poorly differentiated squamous cell carcinoma. Imaging included a positron emission tomography (PET)/computed tomography (CT) scan that demonstrated the right tongue lesion as well as hypermetabolic right level II adenopathy. The patient underwent surgical excision of the right tongue, upper aerodigestive tract endoscopy, and a bilateral supraomohyoid neck dissection. The tongue defect was closed primarily. Results: Final pathology of the surgical specimen demonstrated myoepithelial cell carcinoma. All of the margins were free of tumor and no cervical lymph nodes showed metastasis. Immunohistochemistry demonstrated myoepithelial differentiation. The tumor did not show EWSR1 gene rearrangement on genetic testing, suggesting salivary gland origin. Multidisciplinary tumor board evaluation recommended no adjuvant therapy. The patient recovered well after surgery and nearly a year later is without evidence of recurrent or residual disease. Conclusions: We present the first reported case of myoepithelial cell carcinoma with primary origin in the oral tongue and review the available literature on this unusual tumor. We discuss the clinical, pathological, and immunohistochemical features and treatment of myoepithelial cell carcinoma.

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“…7 At the time of publication, all current case reports of primary tongue MCC describe tumors that appear to have originated in the base of tongue. 8,9…”

Section: Discussionmentioning

confidence: 99%