Small cell carcinoma of the appendix

O'Kane, Anna M; O’Donnell, Mark E.; Shah, Rajeev; Carey, Declan; Lee, John

doi:10.1186/1477-7819-6-4

Cited by 11 publications

(10 citation statements)

References 15 publications

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“…3 However, pure EPSCC of the appendix is extremely rare and there has been only one such case previously reported in the English medical literature. 2 To the best of our knowledge, this is the first Korean case of a pure EPSCC of the appendix and it is only the second reported case of a pure EPSCC arising from the appendix in the English medical literature.…”

Section: Discussionmentioning

confidence: 79%

“…In particular, we performed immunohistochemical staining by using a large panel of antibodies to characterize this tumor and to compare it with the two previously reported cases. 1,2 To the best of our knowledge, this is the first case of a pure EPSCC of the appendix in Korea and it is only the second reported case of a pure EPSCC of the appendix in the English medical literature.…”

mentioning

confidence: 81%

“…Although one case of mixed EPSCC associated with an intestinal-type adenocarcinoma has been previously reported, 1 pure EPSCC of the appendix has been reported only once in the English medical literature. 2 We report here on a case of 55-year-old Korean woman with a primary pure EPSCC arising from the appendix. In particular, we performed immunohistochemical staining by using a large panel of antibodies to characterize this tumor and to compare it with the two previously reported cases.…”

mentioning

confidence: 97%

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Primary Extrapulmonary Small Cell Carcinoma of the Appendix - A Case Report -

Park

Roh

et al. 2010

Korean J Pathol

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Primary extrapulmonary small cell carcinoma (EPSCC) of the appendix is an extremely rare entity, and there has been only one previous report on this in the English medical literature. We report here on the first Korean case of EPSCC of the appendix in a 55-year-old woman. The patient had no history of an identified pulmonary tumor, and she presented with constipation and lower abdominal pain. The patient underwent right hemicolectomy with regional lymph node dissection and bilateral salphigo-oophorectomy. The histology of the entire appendiceal tumor revealed pure EPSCC with diffuse immunoreactivity for pancytokeratin, cytokeratin 7, cytokeratin 20, CD56, thyroid transcription factor 1, c-kit and carcinoembryonic antigen, and there was focal weak immunoreactivity for chromogranin A and synaptophysin. After the second cycle of chemotherapy, the condition of the patient gradually deteriorated due to cancer peritonei and the patient died 7 months later. EPSCC of the appendix is a distinctive clinicopathological entity that displays highly aggressive behavior and an unfavorable outcome.

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Section: Discussionmentioning

confidence: 79%

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confidence: 81%

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confidence: 97%

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Primary Extrapulmonary Small Cell Carcinoma of the Appendix - A Case Report -

Park

Roh

et al. 2010

Korean J Pathol

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“…In case of doubt additional parameters are examined to separate SRC from carcinoid, adenocarcinoma, squamous cell carcinoma (SCC), goblet cell carcinoid, and mucinous adenocarcinoma. Newly applied markers include CK-7, CD45 (LCA), CD99, CD56, and WT1 [14]. In our patient positivity for the epithelial marker CEA was determined.…”

Section: Discussionmentioning

confidence: 99%

A Case of Signet Ring Carcinoma of the Appendix: Dilemmas in Differential Diagnosis and Management

Mastoraki¹,

Papanikolaou²,

Kanakis³

et al. 2010

J Gastrointest Canc

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“…In a series of cases of EPSCCs reviewed, the most common sites were the gastrointestinal and genitourinary tract [4e6]. Primary EPSCC has been described in different organs, including pleura [7,8], thymus [2,4,8], kidney [8,9], bladder [2,4], prostate [10,11], epididymis [12], endometrium [2], uterine cervix [2,13], ovary [2,4], salivary glands [1,2,4], sinuses [2,4,14], larynx [1], trachea [1], thyroid [4], lymph node [4,15], central nervous system [4], bone [15,16], skin [1,15], peritoneum [4], stomach [4e6,11], esophagus [2,17], liver [4,15], gallbladder [18], pancreas [11,15], appendix [19], and colorectum [4,6,20]. Primary peritoneal carcinomas are relatively rare [21].…”

Section: Disscussionmentioning

confidence: 99%

Primary small cell carcinoma of the lesser omentum

Feng

Guo

Chen

et al. 2012

The Kaohsiung J of Med Scie

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Although pulmonary small cell carcinoma (SCC) is seen frequently, SCC that originates from the extrapulmonary organs is extremely rare. We herein report a case of a SCC located in the lesser omentum. A 61-year-old male was admitted to our department due to intermittent epigastralgia for 2 months. Ultrasonography (US) revealed an irregular hypoechoic mass measuring about 58 mm × 50 mm × 45 mm under the left lobe of the liver. Magnetic resonance imaging (MRI) was performed to verify the irregular mass with T1- and T2- weighted images between the left lobe of liver and the stomach. At laparotomy, the well-circumscribed neoplasm was found in the lesser omentum, and the fundus of the neoplasm was located in the root of left gastric artery. Intraoperative microscopic evaluation of frozen sections revealed malignancy of the lesser omentum. Resection of the neoplasm was performed, and the combined resection of the vagal nerve was also performed for the partial adhesion. Pyloroplasty was performed for avoiding delayed gastric emptying caused by combined resection of vagal nerve. The lymph nodes dissection at lesser curvature and right cardia was also performed with a negative result. Based on the histological findings, the final diagnosis of primary lesser omental SCC was confirmed. The pathologic staging showed locoregional disease.

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Small cell carcinoma of the appendix

Abstract: This is the first reported case of a pure extrapulmonary carcinoma arising from the appendix.

Cited by 11 publications

References 15 publications

Primary Extrapulmonary Small Cell Carcinoma of the Appendix - A Case Report -

Primary Extrapulmonary Small Cell Carcinoma of the Appendix - A Case Report -

A Case of Signet Ring Carcinoma of the Appendix: Dilemmas in Differential Diagnosis and Management

Primary small cell carcinoma of the lesser omentum

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