Small cell carcinoma of the endometrium: A clinicopathological study and management of three cases

Sidibé, Fatoumata; Zakaria, Traore; Georgala, Aspasia; Kanab, Rajae; Larsimont, Denis; Awada, Ahmad; Piccart‐Gebhart, Martine

doi:10.1016/j.bulcan.2018.06.007

Cited by 5 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, there is currently no consensus regarding chemotherapy regimens. Most studies recommend a combination of etoposide and platinum-based treatment for small cell lung cancer [17,21]. Additionally, some reports have utilized a combination of Taxol and platinum-based agents, which aligns with the treatment approach for endometrial non-NEC [22,23].…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine carcinoma of the endometrium: a retrospective analysis of data from a single center

Liu,

Tian,

Yan

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

Background Neuroendocrine carcinoma (NEC) originating from the endometrium is rare, and there is limited knowledge regarding its diagnosis and optimal management. In this study, we present our experience with 11 patients with endometrial NEC, aiming to provide guidance for clinical practice. Methods We retrospectively collected the clinical, pathological, and treatment data of 11 patients with endometrial NEC who were treated at the First Affiliated Hospital of Zhengzhou University from January 2011 to July 2023. The clinicopathological characteristics, treatment and prognosis of these patients were analyzed. Results The median age of the patients was 55.0 (39.0–64.0) years, and the median tumor size was 40.0 (33.0–60.0) mm. Irregular vaginal bleeding was the most common symptom observed in 10 out of 11 patients, while metabolic syndrome occurred in only 2 out of 11 patients. Six out of the 11 patients were diagnosed at an early stage. Among the patients, 6 were diagnosed with endometrial NECs, while the remaining patients had a combination of endometrial NEC and other non-NEC endometrial carcinomas. All patients underwent surgery, except for one who received only chemotherapy due to multiple metastases. After surgery, adjuvant chemotherapy was administered to 5 patients, chemotherapy combined with radiotherapy was given to 3 patients, and 2 patients did not receive any adjuvant therapy. A total of 10 patients completed the follow-up, with a median follow-up time of 51.0 (14.3–81.0) months. Unfortunately, 2 patients died from the disease. Conclusion NECs originating from the endometrium might not be affected by metabolic disorders. Preoperative diagnosis of these tumors was challenging. The primary approach for managing endometrial NEC can be multimodal treatment centered around surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuroendocrine carcinoma of the endometrium: a retrospective analysis of data from a single center

Liu,

Tian,

Yan

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…The diagnosis of SCNEC requires at least 1 positive neuroendocrine marker: CgA, neuron-specific enolase, Syn or CD56. [13,17] Immunohistochemical results of the L/SCNEC of the endometrium are listed in Table 2. This case series show that CgA and Syn are positive in most NECEs.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the rarity of NECE and the lack of prospective data to guide treatment, there is no standard treatment guideline for such tumors, and its treatment is based on the traditional treatments of endometrial and small cell lung cancer, like surgical resection, radiation therapy, and chemotherapy. [17,19] Unless the patient wishes to preserve her fertility, the main treatment for endometrial cancer is panhysterectomy, bilateral salpingo-oophorectomy with lymph node assessment, and adjuvant treatment is given by considering the risk factors of recurrence after surgical treatment. [4]…”

Section: Discussionmentioning

confidence: 99%

Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma

Hu¹,

Jiang²,

Song

et al. 2019

Medicine

View full text Add to dashboard Cite

Rationale: Endometrial neuroendocrine carcinoma is a rare histological subtype of endometrial cancer, divided into low-grade neuroendocrine carcinoma (carcinoid) and high-grade neuroendocrine carcinoma (small cell and large cell neuroendocrine carcinoma). It is characterized by high invasiveness and poor prognosis. L/SCNEC is an extremely rare pathological type of endometrial carcinoma, and the number of reports on this condition is few globally. Patient concerns: A 54-year-old Chinese female presented with vaginal bleeding. Diagnoses: Outpatient hysteroscopy and endometrial biopsy were performed, and the pathological examination revealed that cervix was invaded by endometrial malignancy. The patient underwent a laparoscopic radical hysterectomy was diagnosed with the mixed large and small cell neuroendocrine carcinoma (L/SCNEC) of the endometrium combined with serous carcinoma III C2 (FIGO2009). Interventions: Chemotherapy-radiotherapy-chemotherapy “sandwich” treatment was performed as postoperative therapy. Outcomes: After three chemotherapy circles, the patient showed no evidence of further disease progression. Lessons: L/SCNEC is a rare and invasive disease. Once diagnosed, comprehensive treatments including surgery, radiotherapy, and chemotherapy can prolong the survival of patients and improve the prognosis.

show abstract

Neuroendocrine Carcinoma of Endometrium Convention Treatment Approach to Nanomedicine

Akbar

Hasan

Srivastav

et al. 2022

View full text Add to dashboard Cite

Small cell carcinoma of the endometrium: A clinicopathological study and management of three cases

Cited by 5 publications

References 18 publications

Neuroendocrine carcinoma of the endometrium: a retrospective analysis of data from a single center

Neuroendocrine carcinoma of the endometrium: a retrospective analysis of data from a single center

Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma

Neuroendocrine Carcinoma of Endometrium Convention Treatment Approach to Nanomedicine

Contact Info

Product

Resources

About