Small Breast Cancers: In Vivo Percutaneous US-guided Radiofrequency Ablation with Dedicated Cool-Tip Radiofrequency System

Abstract

A dedicated breast cool-tip RF ablation system can induce complete tumor necrosis and reproducible ablation volumes independently of breast glandular pattern, providing excellent cosmesis. Postablation MR images are a reliable tool in predicting histologic findings.

Percutaneous local ablation of unifocal subclinical breast cancer: clinical experience and preliminary results of cryotherapy

“…The cells survived from the direct freezing, die of ischemia and structural damage (delayed cell damage). In the current practice, the radiofrequency ablation (RF) system is the most useful and promising technique among all the applied techniques of percutaneous ablation for the treatment of breast cancer smaller than 2 cm [6,7] . Problems and limitations related to the use of radiofrequency as a physical principle of percutaneous breast cancer ablation are largely attributable to insufficient tumour ablation, to the lack of a real-time imaging that allows to effectively monitor the procedure, to possible side effects on the skin, to the literature absence of significant samples of patients and/or sensitive distant follow-up.…”

“…Percutaneous cryoablation of subclinical breast cancer can be considered an effective ablation technique, repeatable, painless and at low morbidity. In particular, it became clear the analgesic effect of coldness, compared to radiofrequency [7]. In terms of cosmetics, cryoablation represents many significant Fig.…”

Non-surgical therapy and radiologic assessment of stage I breast cancer treatment with novel enzyme-targeting radiosensitization: Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, type II (KORTUC II)

“…moreover, rFa and cryotherapy demand insertion of a moderately large needle into the breast (5-7). General anesthesia is essential to carring out rFa (5,6), mri scanners to monitor the thermal distribution of FuS may be prohibitively expensive (3,4), and FuS takes too much time (3,4). it is also important to note that these non-surgical approaches to therapy require adjuvant radiation to non-ablated tissue in order to exterminate residual cancerous tissue (3-7).…”

“…thus, nowadays, local control is expected to be minimally invasive on the basis that permanent curability is estimated to be comparable. Various types of non-surgical ablation have been introduced as a local control for early breast cancer that also achieve cosmetic gains (3)(4)(5)(6)(7). a new enzyme-targeting radiosensitization treatment containing hydrogen peroxide and sodium hyaluronate for percutaneous injection, kochi Oxydol-radiation therapy for unresectable carcinomas, type ii (kOrtuc ii) (8), was recently developed.…”

Epithelial-smooth muscle cooperation is needed for brain natriuretic peptide-dependent bronchorelaxant activity

“…Remodelling leading to airway smooth muscle thickening has been reported in experimental models of repeated exposure to allergens [10] and reported to characterize arterial vessels during extensive fibrotic and emphysematous lung remodelling [11]. Additional research is needed to clarify the mechanisms of inflammatoryinduced airway smooth muscle hyperplasia in asthma and COPD and the possible contribution of circulating and resident stem cells [12], similarly to vascular smooth muscle cells with aging and cancer [13][14][15][16][17], and to verify the efficacy of new stem cell-mediated therapies [18,19]. The prevalence of synthetic and proliferative features may better explain the airway smooth muscle remodelling and the increased expression and/or function of signalling molecules essential for muscarinic receptor-mediated contraction and the different response to pharmacological stimulation [20].…”